Hello

The BMI poll got a lot of votes so I figured that I should create another poll as it seems to generate interesting discussions.

The question is:How much do you think a correctly practised CR diet can extend the human lifespan assuming the restriction is severe(around 40%) and started at age 20?

The poll choices is the number of extra years beyond average life expectancy assuming it is 80 years.
Please motivate why you voted as you did

Looking forward to the discussion as there are so many experienced people hanging here.

let's see how it proceeds.........

Depends on what age someone starts it. It is more of a percentage thing, right? If someone started it at 80, right before they were going to croak, I don't think it would add much, but if they started it at 40 it would add quite a bit.

This post has been edited by Live Forever: Apr 19 2008, 09:19 PM

Since i'm a chronic optimist i say that CR will add 20 to 30 years to human lifespan, if started earlier (at 20-40 y.o.) and done properly, with supplementation.

This post has been edited by sam988: Apr 19 2008, 10:07 PM

Well I'll vote for 20-30 years too, Maybe 40 if done very severely and started at age 20.Does anybody know why Aubrey De Grey doesn't believe in cr?

http://www.fightaging.org/archives/000564.php

I tend to agree that CR isn't going to add anything much to maximum lifespan, but it will of course add a good bit to average lifespan.

Voted for 20-30 years too, but it may depend on when you start too. If you start CR when you're 17 or 19 you may live to be a 110!

Well I think that the average CRer starting at around 20 - 30 years could probably expect to easily reach 100 assuming they're not unlucky and have terrible genetic predisposition to disease. Otherwise it could just normalize life span which is good thing in it self !

I think the average age reached by long term CR would be around 110-115 years if starting at a young age. Our aging process will have been slowed and disease risk diminished that of the what we see in Super Centenarians of today... the characteristics that help a person become a super centenarian are probably present in CRers.

There is no doubt we can alter the process of aging in mice, you get two groups of genetically identical mice and calorie restrict one of them. The genes already present in an organism can allow for a nice extension of lifespan. I think max lifespan in humans could probably be extended to about 130 years, I think being very optimistic 135-140.

There was one study in Rhesus Monkeys that you might find interesting, the CR group lived on average to 32 years, but were mostly obesity avoidance group. The average Rhesus monkey lives anywhere from 25 - 27 years, similar lifespan to an ad lib humans ( 75 - 81 years). The CR group in this study lived to a human equivalent of 96 human years. This is impressive I think. It has been estimated that humans on an ad lib healthy-ish diet could live on average to 85 - 90 years WITHOUT CR. It will be very interesting to see just how the real anti aging CR diet monkeys do.

This study below showed that CR Monkeys gained 7 years of extra life which is equivalent to humans gaining 21 years of extra life.


Mortality and Morbidity in Laboratory-maintained Rhesus Monkeys and Effects of Long-term Dietary Restriction
Noni L. Bodkin1, Theresa M. Alexander1, Heidi K. Ortmeyer1, Elizabeth Johnson2 and Barbara C. Hansen1

1 Obesity and Diabetes Research Center, Department of Physiology, School of Medicine, University of Maryland, Baltimore.
2 Department of Biostatistics, Johns Hopkins University, Baltimore, Maryland.

Mortality and morbidity were examined in 117 laboratory-maintained rhesus monkeys studied over approximately 25 years (8 dietary-restricted [DR] and 109 ad libitum-fed [AL] monkeys). During the study, 49 AL monkeys and 3 DR monkeys died. Compared with the DR monkeys, the AL monkeys had a 2.6-fold increased risk of death. Hyperinsulinemia led to a 3.7-fold increased risk of death (p <.05); concordantly, the risk of death decreased by 7%, per unit increase in insulin sensitivity (M). There was significant organ pathology in the AL at death. The age at median survival in the AL was approximately 25 years compared with 32 years in the DR. The oldest monkey was a diabetic female (AL) that lived to be 40 years of age. These results suggest that dietary restriction leads to an increased average age of death in primates, associated with the prevention of hyperinsulinemia and the mitigation of age-related disease.

This post has been edited by Matt: Apr 20 2008, 03:57 PM

I thought this was an interesting article

Healthy living 'can add 14 years'
http://news.bbc.co.uk/1/hi/health/7174665.stm

This is also an interesting video on risk factors and reaching mid 80's (9 risk factors) -- this study was in JAMA

http://seniorjournal.com/NEWS/Aging/6-11-1...rchersLearn.htm

There is also a video there too.

This post has been edited by Matt: Apr 20 2008, 03:52 PM

There should be a differentiation between extended average lifespan and max lifespan.

If the cr diet could add extra years to people predisposed to longevity in the supercentenarian range maybe some people could live to 150.

Does anyone here believe that cr could have the same effect to people with supercentenarian genes or do you think that they already enjoy the eventual benefits of cr due to their genes?

maybe a little off topic but does anybody here how many cr practioners there are in the world?I'm talking about people doing it actively motivated by the results on lab animals.

Who in the cr society have currently done cr for the longest time and since when?

This post has been edited by Michael: Jan 3 2010, 12:57 PM

There are only claims of people doing it for decades, one guy named apparently started CR in his 50-60s and lived to 103-104 years (dont remember). Otherwise I think people that claim to do it the longest are Brian Delaney, Lisa Walford, Paul McGlothin, Meredith Averill [CR'd for 14 years) are just a few. Michael. R is probably closing up to 10 years now.

CR Society claim around 2000 people however than number is likely to be wrong [in my opinion]. People who are actively doing CRON properly are probably less than 500.

This post has been edited by Matt: Apr 21 2008, 12:37 PM

Matt:Who was that guy who lived to 104 and started cr at age 50-60,He can't have been counting calories seriously like Michael Rae? If I'm right noone could have been doing CR intentionally before 1985 because it was then Roy Walford made it more known to public...

People have been skipping meals and the like for a long time. In Poor Richard's Almanack, Franklin makes mention of stuff like this multiple times. Even in Shakespeare, there are implications to the benefits of hunger. Which are only two among tons of comments throughout literature about energy restriction.

I voted 5 to 10 years because I don't think it's like stem cell therapy or SENS I think it could help to normaizlize the lifestyle.

Christian Mortensen had a history of always eating moderately,he was also a vegetarian(wouldn't it have been quite unusual having such a lifestyle during all his life by the way). He has had no history of longevity in his family as far as I've read.

He might be referring to Luigi Cornaro, who wrote Discourses on a Sober Life centuries ago.

No I was talking about Ralph who recently just died at 104.

learn more here http://livingthecrway.com/

I can find much information about Ralph and his cr practice on the page.

can't

This post has been edited by Shonghow: May 10 2008, 02:13 PM

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