Interesting article.

http://www.sciencedaily.com/releases/2008/...80325125937.htm

Laboratory experiments showed that resveratrol:

• Reduced the function of proteins in the pancreatic cancer cell membranes that are responsible for pumping chemotherapy out of the cell, making the cells chemo-sensitive.
• Triggered the production of reactive oxygen species (ROS), which are substances circulating in the human body that have been implicated in a number of diseases: when ROS is increased, cells burn out and die.
• Caused apoptosis, which is likely the result of increased ROS.
• Depolarized the mitochondrial membranes, which indicates a decrease in the cell's potential to function. Radiation alone does not injure the mitochondrial membrane as much.

ehh?

Depolarized the mitochondrial membranes, which indicates a decrease in the cell's potential to function. Radiation alone does not injure the mitochondrial membrane as much.


...double eh.

Eh and double eh...perhaps they are talking specifically about the actions within pancreatic cancer cells, not cells throughout the entire body. Maybe we should contact the lead researcher to clear things up.

They used 50 mg/ml, or 219 mM. That's way higher than the micromolar concentrations achievable with oral dosing.

Good point. Oral resveratrol results in serum levels orders of magnitude lower. I've seen serum levels as high as almost 200 nano-grams/ml from an 800 mg dose of a resveratrol formulation. It's possible that chronic exposure to lower levels has a favorable effect, but we don't know what happens in vivo.

What's the latest on intravenous resveratrol? Would it be possible to obtain the types of concentrations that produce in vitro cancer apoptosis in vivo for cancer patients?

Stephen

You can look up clinical trials on the NIH website. I haven't seen anything with intravenous resveratrol.

Stephen,

We are one step closer to it. Publicly, I can say we are currently testing micronized powder particle size for production (I believe its between 4-5um as I write this post). I will know the final size this friday.

A

Send me 30grams and I will take some SEM images for you. How much more will micronized resveratrol cost? Let say for 100grams.

An uncle-in-law was diagnosed with pancreatic cancer last year. He went from Australia to Peru to get treatments. New diet and colon cleansing, basically, i believe. I also got him to start taking 1 g/day of resveratrol and 4 g/d vitamin C. I don't know how well he's sticking to it, but I'll keep on him about the resv. After new images were taken this weak in Australia, a team of doctors came in to interview him to find out what the hell he was doing. He said he was so mad at them for not having a clue and only knowing about chemo (which he refused until he had finished treatments from the German doctor in peru) that he said 'I stopped eating meat.' This is about 1.5 years after the cancer first began showing symptoms and now he feels better than ever.

Hi Hedge,

pricing has not been established just yet, When it is, it will be added to the price watch thread.

Because we want to have our particle size checked by an independent party, we selected the following University to send us the results regarding particle size:
http://www.fiu.edu/~emlab/home.html

They mentioned that their results will be completed within 7 days of receiving the material.

thanks
A

Sounds good, I guess my point is that you could send me a sample and I wouldn't charge anything and if it needs to be processed more you wouldn't have to pay to have images or a particle size analyzer tested more then once

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