Thats the thing, with this drug you can actually feel it working, you feel mentally more stimulated, you can't really say the same for the nootropics. I have seen other reports like this where the user has felt no side effect or tollerance. If this drug really does turn out to safe long term just imagine how much more productive you could be in your life, you would have the edge over everyone!

I use modafinil, but only because it enables me not to fall asleep during my work day if I haven't slept enough the previous night. I get no useful mental stimulation out of it, no increase in drive or mood (or barely), at 50mg x 2 or x 3 as needed.
It's very useful that way I find...

Thanx for the info da_sense. I dont have a doctor(cant afford one). Modafinil is primarily safe right? If I get some Im not gonna take it every single day. Just once a week, maybe twice.

guyledouche
Yes, Modafinil is safe even if you take it every single day. What i'm advising safe use i primarily mean not geting "addicted" to it. It's not "addictive", but anything that gives you more of something is addictive (smoke, alcohol, coffee...etc).

Anyone have any experience with
pharm-marketing.com

They're offering Modafinil powder at
$1200/kg.

http://www.pharma-orders.com/product_info....973d6836425dc27
Compared to $6599/kg



Could be a good deal. Thoughts?
Anyone know of a better source?

7. Modafinil (Provigil)
Chemical Name: 2-[(diphenylmethyl)sulfinyl]acetamide
CAS NO.: [68693-11-8]
Structural Formula:

Molecular Formula: C15H15NO2S
Molecular Weight: 273.36
Appearance: White to off-white crystalline solid
Solubility: practically insoluble inwater and cyclohexane. It is sparingly to slightly soluble in methanol and acetone
Melting point:164-166 DEG C.
Residue on ignition: 0.2% max
Loss on drying: 0.5% max
Assay: 98.5% min
Heavy metal: 20 ppm max
Uses: It is a wakefulness-promoting agent for oral administration
Packing: Aluminium or iron tin lined with plastic bag.

Could you let me know what brand your using...?

I'm pretty sure those amounts are considered a stupidly heavy dose from what I've read. BUT what you said sounds very similar to my (limited) experience so far -- except for the anxiety bit. I've been using Modalert, which I've read in many places is way inferior to other brands...

The authors of that impressive Neva Press article about Adrafinil (the "mother" molecule for the Vig) termed Adrafinil a nootropic (for those of us "unscientific" folk); so it depends what your definition of nootropic is. A nootropic drug, in my "medical" definition would seem to define a drug that would positively affect cognition or memory.



I have taken US "Provigil", "Mexican "Modiodal" (which is actually made in the USA, believe it or not!), and Indian "Modalert" or "Modafil." I have noticed no difference in the effects from any of these brands. And I have been taking modafinil or adrafinil for about four years now. I depend on it to work such that if it did not I could easily tell -- I get all pumped up on 300mg modafinil before I go to the gym -- and after a two and a half hour work out, I still have energy -- but I can go right to bed a couple hours later.

I guess it could be placebo effect, but it would have to be a darn powerful sugar pill to have that much kick. Also, days of a big exam, I often awaken SUPER early -- like 3 am sometimes if it's a big test -- and you bet I would pass right out without 250mg modafinil. But that's just me. I sound like I'm addicted to the stuff, eh? Well I'm a competitive person when it comes to school and workout -- so anything that can give me an "edge" without a barrage of negative side effects, I am into it. And modafinil has been used in clinical studies as far back as the early 1980's -- when it was tested as a "vigilance agent" in elderly folks. Thus far there have been scant reports of any significant side effects of this novel drug. So I think it's pretty safe.

I would not be at adverted to sending a sample of Sun's modafinil to Integrated Biomolecule for an assay. I think the cost would be about $250 for the active in one pill. Anyone want to pitch in?

Hi everyone :D I would like to preface my comments by stating that I am a physician who was experiment with "nootropics" for approximately 8 years on and off. I have tried nootropics including piracetam, aniracetam, deprenyl, as well as a few others. With both pracetam and aniracetam, I subjectively felt that it may have some positive 'noootropic' effects including improvements in the flexibility and creativity of my thinking. However, both of these seemed to decrease my mental energy during study sessions in medical school. I would find I would literaly 'hit the wall' after a set number of hours and would no longer be able to focus/study without sleep. In fact, during periods of reduced sleep, I found that both of these nootropics actually seemed to have negative effects. In short, I only found these nootropics to use at times in which I was writing medical publications. Several of my medline publicatios were written while taking these nootropics. [however this is a pseudonym]

Deprenyl--in short, did absolutely nothing positive for me and seemed to cause me to have a dysphoric mood experience. Your experiences with this may vary, however...

***My most positive experience with a nootropic, for use as a study aid, was without question centrophenoxine. I found that it dramatically improved my concentration and recall, but little else. I did not experience any improvements in my ability to think, in fact, to some extent it seemed to reduce the flexibility of my thinking, much like I would expect something like ritalin would do as well. However, with the use of centrophenoxine, I was able to elevate my grades to the top 10% of my class from the top 30%. IMO, a program such as medical school mostly taxes one's memory ability as opposed to any other mental faculties.

Lately, I have been experimenting with Modafinil. I would advise anyone else who does this to have baseline liver function tests taken as well as routine monitoring of their LFTs. It is true that adrafinil is more hepatotoxic, but it is better to be safe than sorry... Though I have only used this drug for a few days, I can report that it certainly improves wakefullness during periods of reduced sleep. As well, it seems to dramatically improve my ability to concentrate. I suspect these are the only benefits that this drug has to offer. I also will note, that at doses of 200mg I started to feel somewhat more anxious.

Final note, several years ago I tried Hydergine. I recall it having a mild stimulant effect with a definite improvement in concentration. However, my overall experience with this drug was negative. I recall experiencing somewhat of an up and down flux in my energy reflecting changes in my blood levels. I suspect it has a short half life, but am not certain of this. I would not advise using this drug as my overall opinion is that it is not very good.


warm regards,

Hello. It's good to hear healthy criticism on nootropics as it helps to discriminate between useful and nonuseful. It's interesting you mention that ritalin would decrease mental flexibility, because this is what I've tried to pinpoint for some time why it seems to have a negative effect on my cognition apart from increasing concentration and mental energy. I feel it abolishes my creativity extensively, making me blind to see more abstract connections between things. Any particular idea why it does that?

Interesting notes. I would have to say Centro and pyritinol might have been the only nootropic that I have tried where I *might* have felt something beyond placebo. I ordered both at the same time and tried 250 mg Centro + 400 mg Pyritinol and it seemed like my concentration improved. However, I have repeated the experiment and tried each individually with only mixed results. Nothing bad, but just was not sure if the substances were doing anything. Modafinil (Modvigil) was good for about the first three or four hours. I felt really alert and did not notice mental fatigue after studying for over an hour. However, around hours 5-6, I felt this feeling of perpetual brain fart -- similar to what I felt when I experimented with Adrafinil for the first time. By the way, how did you get modafinil? Did you write yourself a prescription? This may seem very naive, but can doctors do that?

Couldn't find hepatoxic in any dictionary. Are we talking hepatotoxic, hepatic or hypoxic here?
Is hepatoxic something else?

This post has been edited by systemicanomaly: Sep 2 2006, 10:58 AM

adrafinil is somewhat hepatotoxic, guess he simply made a typo

I'M A RN, HEPATO=LIVER, everything gets "detoxed" through the liver, but like Tylenol, Adrafinil, even more so, is especially hard on the liver

they sell you by the kg? don't do it.

It should be noted that the following racetams ALL have slight ampakine effects:
Piracetam
Oxiracetam
Aniracetam
Pramiracetam


Nefiracetam, however, would be an amazing ampakine synergist due to it's nemdakine properties. Simultaneous administration of nemdakines and ampakines synergize the effects of ampakines 10-fold. Good to know for those who would rather make their $95 for 15 grams of CX-516 go for half a year than for a few weeks.

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