Resveratrol extends lifespan in mice and health

I have found that Polygonum cuspidatum (pc) varies considerably from source to source. By selecting for it as one principal criteria it is possible to keep levels in the finished product down to a very tolerable level, certainly well below the amount that could cause actual diarhea. There are also means of further reducing the concentration during processing. At a dose of 1.5 gm per day it is not a problem for me. By taking the dose with food the effect is further diminished.

Maxwatt: my intake is 240mg Resveratrol (from Country life, 2x100mg Resveratrol and 2x 20mg from Pomeratrol 120mg in the morning and 120mg in the evening) and i have no Problem at all. I am quite happy at this level since that gives me 4.4mg/kg. I'd like to add 37.5mg Resveratrol from the Nautre's Way Product since that has mixed Redwine Polyphenols in it but alas it is not in stock and i just made a large order so ill just wait till my next restock. Till then i'l just have to get by with this low amount. ;-).

But thanks for your information.

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Maxwatt: my intake is 240mg Resveratrol (from Country life, 2x100mg Resveratrol and 2x 20mg from Pomeratrol 120mg in the morning and 120mg in the evening) and i have no Problem at all. I am quite happy at this level since that gives me 4.4mg/kg. I'd like to add 37.5mg Resveratrol from the Nautre's Way Product since that has mixed Redwine Polyphenols in it but alas it is not in stock and i just made a large order so ill just wait till my next restock. Till then i'l just have to get by with this low amount. ;-).

But thanks for your information.

Hey curious_sle,
How's that does been treating you? Any short term effects of note? how long have you been doing this?
Your info is considered of value to us members.
I am using Biotest's Rez-V which has 100mg per capsule, supposedly of pure resveratrol (source not given). I use between 50-300mg on various days... trying to notice any immediate differences... maybe some increase in energy of late?

nah no real discernible changes in mood etc but then again i'm a fairly stable person and don't change much. I'll know more about a few baseline parameters in april after my next bloodworks (had a panel before going from good old 20mg :-) to 240 which was like a week ago).

So, no ill effects no positive effects thus far.

nah no real discernible changes in mood etc but then again i'm a fairly stable person and don't change much. I'll know more about a few baseline parameters in april after my next bloodworks (had a panel before going from good old 20mg :-) to 240 which was like a week ago).

So, no ill effects no positive effects thus far.

Appreciate that... great having people such as yourself doing bloodwork, etc... to guage possible benefits/negatives of supplements. Make sure you post your results and observations in 2007!!

This is weird. Have your own body make resveratrol. For research purposes only.

With a new picture of a bacterial enzyme in hand, Howard Hughes Medical Institute scientists are now on their way to making “chemical factories” that will help laboratory animals produce their own resveratrol — the compound behind red wine’s frequently touted health benefits.

With Andrew Dillin, they are creating worms that produce resveratrol in the muscle, where it is thought to speed up metabolism. They are engineering mice that produce resveratrol in the muscle, as well, in collaboration with HHMI investigator Ronald M. Evans, also at the Salk Institute. With Leanne Jones, they are producing fruit flies that produce resveratrol in the stem cell niche - a population of cells that is suspected to be involved in regulating longevity. And with Fred H. Gage, they are creating mice that make resveratrol in the neurons in the brain that decline rapidly when struck by neurodegenerative diseases — another potential place resveratrol may exert beneficial effects.


These projects, already underway, are only the beginning of what Noel has planned. Also on the list are animals that produce resveratrol in the liver and special cells in the pancreas that produce insulin. Noel said that by tweaking the ammonia lyase enzyme and other enzymes in the chemical factory in small, targeted ways, his team should be able to genetically engineer animals to produce modified versions of resveratrol. This would give the scientists the opportunity to investigate how a slightly different chemical structure might alter resveratrol’s effects in different tissues.

http://www.webwire.c...l.asp?aId=25569

Has anyone seen any changes in their blood pressure since taking larger doses of resveratrol? I upped my doseage from 20 mg per day (LEF) to 200 mg twice a day (Longevatrol) about 7 weeks ago. Anecdotally, I seem to have more energy, but my blood pressure has changed signiicantly (at least it seems significant to me). I'm not sure when it changed, it could have been over the last year and had nothing to do with the resveratrol. But it has gone from like 80 over 60 or maybe 90 over 70 to 130 over 80. The doctor did not seem too concerned about it today during a routine helath checkup, as I am almost 52 and I guess it is supposed to go up with age. But I am curious to see if anyone else has had any similar changes since increasing their doseage of resveratrol.

Blood pressure doesn't have to go up significantly with age.

Thanks velopismo, it is interesting to see the how/why of his approach. I am glad he is working on it!

http://www.webwire.c...l.asp?aId=25569

Maxwatt,
Although my inclination until now has been to ignore your comments regarding our company and our product I am afraid I can no longer restrain my consternation over your innunendos and derogatory conjectures and accusations. If you would have taken the simple courtesy of inquiring of our company before posting your slander we would have been happy to discuss any of the issues you allude to in your postings and present our case to you in a civil and professional manner. In respect to your actual statements, I will make this brief. First, everything set forth or described on the bioflu website is true, accurate and we stand behind it 100%. Second, our product has been challenged before by skeptics with strong credentials and in every instance we have proven our product to be exactly as it is described. We guarantee that Bioforte conforms to the specifications and quality parameters noted on the site and our customers have been more than satisfied to date. Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.

Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.

Could you provide a bit more information about Biotivia? Googling for "Biotivia Neutraceuticals " or "Biotivia Nutraceuticals" returns nothing, and www.biotivia.com is just a junk page parked at GoDaddy. This seems strange for a company that deals with "universities, researchers, and formulators".

On 12/21 you claimed "The product used in this study is called Bioforte". Some assumed you were referring to Sinclair's study, and that you were being dishonest. I find it surprising that you made no effort to clear up this misunderstanding.

As I said in a different thread, I'd really like to find that your product is what you claim it to be. If you could demonstrate this to us, I think you'd likely pick up at least a few customers in the short term, and the positive exposure on this forum would do wonders for your business in the long term.

Establishing your legitimacy will require more than you have provided. Tell us who did the analysis on your product and show us convincing documentation to that effect. Prove your connection to your parent company, and tell us who their customers are. If you have credentials in this industry, let's see them. As the general manager of your company, surely you can find a way to build trust with your potential customers.

Maxwatt,
Although my inclination until now has been to ignore your comments regarding our company and our product I am afraid I can no longer restrain my consternation over your innunendos and derogatory conjectures and accusations. If you would have taken the simple courtesy of inquiring of our company before posting your slander we would have been happy to discuss any of the issues you allude to in your postings and present our case to you in a civil and professional manner. In respect to your actual statements, I will make this brief. First, everything set forth or described on the bioflu website is true, accurate and we stand behind it 100%.  Second, our product has been challenged before by skeptics with strong credentials and in every instance we have proven our product to be exactly as it is described. We guarantee that Bioforte conforms to the specifications and quality parameters noted on the site and our customers have been more than satisfied to date. Bioflu is owned by Biotivia Neutraceuticals who supplies research grade ingredients to universities, researchers, and formulators. We are no fly-by-night operation as you seem to imply.

Biotivia.com is a parked domain, but there is a page in that domain that points to the bioflu page (below). This is not exactly the sort of thing to inspire confidence, but I am willing to suspend disbelief. I also see that this major supplier to universities, researchers, and formulators is having trouble procuring product:

http://www.bioflu.co...CFSE2OAodbRyJNQ

A google search for biotivia turned up some paid internet advertising and some viral marketing.

NONE-THE-LESS, this could be a cost-effective and useful product for many of us. I could be all-too-willing to overlook your skeezy and contemptuous marketing attempts. (I do hate packing my own pills.) There is just one major problem we have at this point. What is the emodium content of your product? Although there are ways to lower it, a typical 50% resveratrol extract from P. cuspidatum contains 20% emodium. Emodium is a fairly potent cathartic. At this level, the amount of emodium in one of your 500 mg pills would have most people jumping on and off the toilet for 3 days. Outside the commode they would be audibly and fragrantly flatulent. Not a pleasant side-effect.

There are ways to reduce the emodium content, but even at 1 to 3% many people will be uncomfortably "loose." Ten miligrams is too much emodium for some people. Until proven otherwise, I will assume this is a problem with all high-dose resveratrol products on the market. This information should be on the label.

I will stop "maligning" your pills by stating my very valid reservations, if you answer one question: what is the quantative emodium content of your product? Give me a 10 gram sample and I can analyze it for you for about $300*, or have an independant lab do it for about the same price. If you post an image of the analysis on your website, showing the independant labs' letterhead, with name and phone number, no one will have any doubts. It's a worthwhile investment for you.

Anyone can get a Chinese 50% resveratrol extract for about $125 a kilo and pack it into capsules and put them in a bottle with a pretty label; what is critical is the emodium content (among other things.)

*analysis: percentages of trans-resveratrol, cis-resveratrol and emodium by HPLC, heavy metal as lead, bacterial plate count.

Edited by maxwatt, 01 January 2007 - 07:22 AM.

I meant "10 MILLIgrams is too much emodium for most people." and have so edited the post above.

Edited by maxwatt, 01 January 2007 - 07:22 AM.

There is an upcoming conference on Natural Supplements (January 19-21, 2007)...more information can be found here.

Here's a teaser:



I'd like to hear what specialists from the field of integrative medicine have to say on the matter...

Just a heads up: Nova ran a segment last night on genetic targets of aging. Sinclair and Guarente are featured on Sirtuins and resveratrol, and some other top researchers are interviewed about their pet genes, including daf-2, which some of you may recall from longevity studies on C. Elegans from recent years, and CEPT VV, a mutation associated with longevity in Ashkenazi Jews. (Personally, I'm convinced the latter is present in my mother's family. They all live deep into their 90's with critical faculties intact. Dad's side not so good. I wonder if I could get tested to see if I have CEPT VV?) In any event, the Nova segment is for popular consumption, doesn't really tell us anything we don't know, and is only 13 minutes long. Nevertheless, it was fun to see, and I offer up this link for entertainment purposes only:

http://www.pbs.org/w...ow/3401/01.html

Correction: The gene is CETP VV. Sorry about that.

it was fun to see, and I offer up this link for entertainment purposes only

Great clip. Interesting info to me: they say low insulin levels kick off the survival genes: a great reason to limit the protein in diet to 1-1.5(2)G per KG/bodyweight (hold off with the 30G+ protein shakes and the massive steak) to limit insulin secretion, due to the breakdown product from protein, and focus more on LOW glycemic carbs and healthy fats for longer life.
Climbing the genealogical tree, I see my family surviving better on lower protein-caloric diets, - my little brother is not really on a super healthy, balanced diet, but he probably hasn't eaten much protein in his life, - being rail-thin and not really looking so old.

I lived on mostly three large bowls of wholegrain cereal for much of my teenage years, my only high protein source was Healthy living (low salt, sugar) baked beans. I only ate red meat a few times in my life, hardly ever ate any lean meats. Also quite a bit of junk food like milk chocolate, but never loads... I got very little protein in my diet and always been real thin. I'm 22 years 2 months old at the moment... I think I look quite young, at least people say I do. You can see by click on my profile (new pic). Usually get away with being around 16-17 lol. Although, at all ages I've always looked far younger than my friends the same age.

Edited by Matt, 11 January 2007 - 07:17 AM.

some more information on this subject .. red wine is the highest source of resveratrol ... since the grapes are fermented with the seeds and skins to process this ... but regular grape juice contains about 60% the R content as wine, minus the alcohol of course.

Peanuts also are a high source of resveratrol as well.

What's interesting is that the health benefits due to red wine might have nothing to do with resveratrol at all, yet articles always compare the number of glasses of red wine it would take to equal such-and-such a dose of resveratrol.

Stephen

It's been fairly well establised that resveratrol is the main ingredient that does the job. Other antioxidents also contribute their bit. Why is it nobody ever mentions the res found in whole grapes? You see people constantly talk about wine and sometimes grape juice but never grapes. That's because the media has not talked about it so it has not registered on people's minds. Grapes and raisins are full of res.

Has it been? Any citations?

Stephen

I have a question. Does anyone know if bioperine may increase the bioavailability of Resveratrol? Recently, I took a dose of Resveratrol with bioperine and had no ill effects. I did this to see if I would experience something different. I usually take Curcumin plus bioperine because pairing these two increases the bioavailabilty of curcumin.
I will tell you this. Two weeks ago, I took my Resveratrol along with a dose of Curcumin/Bioperine and it made me feel "agitated" for some reason. Has anyone experienced this?
Also, is it true that pairing Resveratrol with Quercitin negates the effects of Resveratrol. I read a while back that the metabolites of Quercetin may block the benefits of Resveratrol. Does anyone have any input on this?
I do notice that if I pair my Resveratrol with quercetin and lecithin that I feel a more positive mood and more endurance in my workouts. Does anyone feel this?

eternalone, check out this topic: Quercetin and SIRT1 (http://www.imminst.o...&f=6&t=13728&s=)
It may or may not be helpful to you.

I currently take resveratrol, ellagic acid, lecithin, grape extract, and quercetin together with a glass of wine with dinner. The positive mood / energy effects are very pronounced, and consistent (and are present whether I drink the wine or not... so alcohol is not the cause). I feel less tired, and have more drive and enthusiasm. Maybe it's all in my head, but hey, its real and helps me so that is all that matters.

It's been fairly well establised that resveratrol is the main ingredient that does the job.

No, it hasn't.

Opales, my understanding is that the resveratrol used by Dr. Sinclair is 100% pure. This would suggest that resveratrol alone is the primary chemical in wine/grapes leading to the French Paradox and other longevity/health benefits. That's not to say that other polyphenols don't somehow contribute or have their own stand-alone benefits.

BTW, Sardi's latest article on resveratrol:
http://tinyurl.com/y7xtql

something I quoted recently

One finding that has often been overlooked is that quercetin, which is also present in red wine, is a picomolar inhibitor of resveratrol sulphation in both the liver and duodenum, indicating that the profiles of metabolites obtained after consumption of either red wine or purified resveratrol could be different.

It is also worth considering the potential interactions of resveratrol with other constituents of the diet. Resveratrol has been shown to synergize with both quercetin and ellagic acid in the induction of apoptosis in human leukaemia cells, with ethanol in the inhibition of iNOS expression, with vitamin E in the prevention of lipid peroxidation, with catechin in the protection of PC12 cells from beta-amyloid toxicity, and with nucleoside analogues in the inhibition of HIV1 replication in cultured T lymphocytes. These effects could help to explain how a relatively low dose of resveratrol obtained from red wine or other dietary sources could produce a measurable health benefit.

so do you still think that resveratrol is the only compound that would explain the french paradox. It's not that simple. We are talking multicellular systems and multifactorial mechanisms.

The source of the above quotes. I'm not quiet sure why people aren't reading this paper considering the amount of jibber jabber I've seen about resveratrol.

Oh yes, Duke, I started to read Bill Sardi's recent artcle

Living On the Vine

Human lifespan

Human lifespan over the centuries

Did anyone really find the secret of longevity long ago?  The answer is, maybe.  Lacking a time-reversal machine, this can only be speculated.  But a review of the subject is certainly intriguing.

Moses lives 120 years

Biblical records.......

I stopped just before he could start quoting the bible. On purpose of course. [thumb]

Yeah, I read the article and wasn't impressed with the reliance on fables to support his argument. This is a far cry from earlier writings of his that I've read on topics like Vitamin C and D, that were professional and scientifically grounded. I suspect financial interests are having some influence here.

What I said was res was the main ingredient that gave the benefits. I never said it was the only good thing out there or the only good thing in wine or grapes. Opales came up with a rip snorting "no it isn't" to refute my statement but that has been quietly rebutted by the facts. It's hard to argue with a study that used pure res and got the results we've all heard about.

I've noticed a stimulant effect with res when I started taking it though I've gotten used to it now. I recently upped my dose from 20mg to 40mg per day and found it harder to get to sleep and to sleep well. I'm hoping it will wear off or that I'll get used to it after a while. I can only imagine taking 400mg a day like some folks.

Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

What I said was res was the main ingredient that gave the benefits. I never said it was the only good thing out there or the only good thing in wine or grapes. Opales came up with a rip snorting "no it isn't" to refute my statement but that has been quietly rebutted by the facts. It's hard to argue with a study that used pure res and got the results we've all heard about.

And what animal was used in these studies?