First, let me please provide some introductory information and the statement of scope by The Journal of Nutrition:
The Journal of Nutrition is published monthly and is an official publication of ASN. Contents include peer-reviewed research papers covering all aspects of experimental nutrition; special articles such as critical reviews and biographies of prominent nutrition scientists; and commentaries on controversial issues in nutrition.
Supplements are frequently published to provide extended discussion of topics of special interest.
A. Catharine Ross is Editor of The Journal of Nutrition. With the assistance and recommendation of Associate Editors (selected for their expertise in specific nutrition disciplines), the Editor accepts or rejects submitted manuscripts. Submitted manuscripts must comply with The Journal of Nutrition's Guide for Authors. Membership in ASN includes a subscription to the online version of JN.
The premier journal in its field, The Journal of Nutrition continues to have as its goal the publication of papers based on original nutrition research in humans and other animal species. In circulation since 1928, it is an official monthly publication of the American Society for Nutrition distributed to more than 4500 subscribers world-wide. The Journal publishes original research reported by authors in over 30 countries. To provide expert evaluation of the various segments of the broad spectrum of nutrition research, the editorial office is assisted by scientists who serve as Associate Editors, Editorial Board Members, and ad-hoc reviewers chosen for their nutritional science expertise. They provide constructive evaluation and fair and rapid editorial processing. Reports of research on the following and other areas of nutrition are published:
o Biochemical, Molecular, and Genetic Mechanisms in Nutrition
o Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions (including Nutritional Toxicities)
o Nutrition and Disease
o Nutrient Requirements and Optimal Nutrition
o Genomics, Proteomics, and Metabolomics
o Nutritional Epidemiology
o Community and International Nutrition
o Nutritional Immunology
o Ingestive Behavior and Nutritional Neurosciences
o Nutritional Methodologies and Mathematical Modeling
The Journal also publishes critical reviews, issues and opinions, biographies, and supplements containing proceedings of symposia or special meetings. The frequency of citations to articles published in The Journal of Nutrition by scientists, clinicians, and others increases each year.
The Journal of Nutrition is focused on the publication of mechanistic studies and studies that advance the scientific understanding of nutritional processes. The Journal of Nutrition seeks to review original manuscripts that address nutritionally relevant topics, based on human or animal studies in vivo, relevant cell and molecular models ex vivo, and relevant mathematical models. Manuscripts received by the Editor are previewed to determine their suitability for review. Manuscripts may be returned by the Editor without external review if the topic of the manuscript is outside the scope of The Journal of Nutrition, or if the topic is judged to be better suited to another type of journal.
Manuscripts based on research that is mostly of a descriptive or categorical nature are, in general, not well suited for The Journal of Nutrition. Exceptions would be descriptive nutrition research that is highly original and novel with respect to the topic addressed. Manuscripts based on clinical data (laboratory findings, treatment comparisons, in-hospital studies) are generally considered better suited for a clinically-oriented journal and will be returned without external review.
Manuscripts concerned with dietary supplements and botanical compounds must demonstrate that the materials used and the conditions in which they have been studied are nutritionally relevant. In general, the compounds tested must be described in sufficient detail to be reproduced by other research laboratories; generally, this means that the material/extract must be of defined composition and/or analyzed sufficiently so that its major active components are known. Studies showing effects ex vivo or in cell culture models must be conducted with physiologically relevant concentrations of the compounds tested, or it must be clearly justified as to why this was not done. Generally, manuscripts based on dose-ranging studies that show a biological effect but do not address a mechanism will be returned without external review.
Manuscript submissions and inquiries are encouraged. Manuscript style and formatting are described in the "Guide for Authors" posted online at jn.nutrition.org/misc/ifora.shtml. Manuscript submissions should be made using The Journal of Nutrition online manuscript submission program (submit.nutrition.org). Direct inquiries to: jnsubmit@nutrition.org
Editorial Office:
A. Catharine Ross
Pennsylvania State University
Department of Nutritional Sciences
126-S Henderson Building
University Park, PA 16802-6504
e-mail: acr6@psu.edu
Here is the study abstract:
© 2007 American Society for Nutrition J. Nutr. 137:2098-2105, September 2007
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Nutritional Epidemiology
Antioxidant Supplementation Increases the Risk of Skin Cancers in Women but Not in Men1
Serge Hercberg2,3,*, Khaled Ezzedine2,4, Christiane Guinot5,6, Paul Preziosi2, Pilar Galan2, Sandrine Bertrais2, Carla Estaquio2, Serge Briançon7, Alain Favier8, Julie Latreille5 and Denis Malvy9
2 UMR U557 Inserm/U1125 Inra/EA3200 Cnam/Univ Paris 13, Bobigny, France 93017; 3 Unité de Surveillance et d'Epidémiologie Nutritionnelle; Centre de Recherche en Nutrition Humaine Ile-de-France UFR SMBH Paris 13, Bobigny, France 93017; 4 Department of Dermatology, University Hospital Erasme, Université Libre de Bruxelles, Bruxelles, Belgium 1070; 5 Biometrics and Epidemiology Unit, CE.R.I.E.S., Neuilly sur Seine, France 92521; 6 Computer Science Laboratory, Ecole Polytechnique, Université de Tours, Tours, France 37200; 7 EA 3444, Ecole de Santé Publique, Epidémiologie clinique, Faculté de Médecine, CHU Nancy, France 54035; 8 Laboratoire Lésions des Acides Nucléiques, UMR CNRS-CEA-UJF 5046, Grenoble, France 38000; and 9 EA 3677 and Centre René-Labusquière (Tropical Medicine and International Health Branch), Université Victor Segalen Bordeaux 2 and Department of Internal Medicine and Tropical Diseases, University Hospital Center, Bordeaux, France 33076
* To whom correspondence should be addressed. E-mail: hercberg@cnam.fr.
This research aimed to test whether supplementation with a combination of antioxidant vitamins and minerals could reduce the risk of skin cancers (SC). It was performed within the framework of the Supplementation in Vitamins and Mineral Antioxidants study, a randomized, double-blinded, placebo-controlled, primary prevention trial testing the efficacy of nutritional doses of antioxidants in reducing incidence of cancer and ischemic heart disease in the general population. French adults (7876 women and 5141 men) were randomized to take an oral daily capsule of antioxidants (120 mg vitamin C, 30 mg vitamin E, 6 mg ß-carotene, 100 µg selenium, and 20 mg zinc) or a matching placebo. The median time of follow-up was 7.5 y. A total of 157 cases of all types of SC were reported, from which 25 were melanomas. Because the effect of antioxidants on SC incidence varied according to gender, men and women were analyzed separately. In women, the incidence of SC was higher in the antioxidant group [adjusted hazard ratio (adjusted HR) = 1.68; P = 0.03]. Conversely, in men, incidence did not differ between the 2 treatment groups (adjusted HR = 0.69; P = 0.11). Despite the small number of events, the incidence of melanoma was also higher in the antioxidant group for women (adjusted HR = 4.31; P = 0.02). The incidence of nonmelanoma SC did not differ between the antioxidant and placebo groups (adjusted HR = 1.37; P = 0.22 for women and adjusted HR = 0.72; P = 0.19 for men). Our findings suggest that antioxidant supplementation affects the incidence of SC differentially in men and women.
This recent report, in addtion to Archives of Internal Medicine: Vitamins C and E and Beta Carotene: No benefit, in the Secondary Prevention of Cardiovascular Events in Women seem to make the antioxidant prescription look sketchy -- at least for the general population -- and now even more so for women...or so it may seem.
For a mainstream version of this story, please click here to read: Health Day News: "Antioxidant Supplements May Raise Women's Skin Cancer Risk Mechanism isn't clear, and new findings don't apply to men."
Thoughts or comments?
Take care.
