Supplements to reduce the incidence and severity

Its difficult to tell the probability of a global pandemic before a vaccine becomes widely available, so, any ideas?

As far as I have been able to find, other than Tamiflu or Relenza

Sambucol - Supposedly inhibits the spread of the virus and strengthens the immune system but increases the chance of cytokine storm.
resveratrol - Supposedly inhibits the spread of the virus, also increases chance of cytokine storm though.

echineachia, vit c, multi vitamins, zinc, SOD increase? all may be of use but I dont have any good information on anything and am only going by what I have read from browsing random bird flu paranoia forums.

So it would be great if anyone could elaborate or offer some suggestions. I have read that Sambucol is selling out pretty fast.

Last flu season I tried echineachia, vit c, and zinc, to both prevent and cure any colds or flu that came along. I caught a couple minor colds, the supps seemed to help, but I can't say for sure that it wasn't a placebo effect.

Also, a local doctor told me that echineachia doesn't "fight" viruses, it just triggers the immune system to get prepared for any unwanted invaders. I haven't read enough myself to know the exact effects of echineachia.

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Offhand, I can think of :

1. Olive leaf extract


2. Arabinogalactan, the polysaccharide from the larch tree.

http://www.ncbi.nlm....t_uids=11322248

http://www.ncbi.nlm....st_uids=8439987

http://betterlife.co...sp?prod_id=2333


3. Monolaurin, or lauric acid, which appears promising.

http://www.lauric.org/lcv.html

http://www.ncbi.nlm....st_uids=8113756

http://www.catie.ca/...81?OpenDocument

http://www.aids.org/atn/a-033-03.html


4. Artemisinin and artesunate, from the Chinese wormwood
tree, has activity against the malaria parasite, and has also
just been found to have strong antiviral properties. Artesunate
apparently also has anticancer action. Nutricology makes
artemisinin.

http://www.ncbi.nlm....t_uids=16122816

http://www.ncbi.nlm....t_uids=11976732

http://www.ncbi.nlm....t_uids=16122816

http://betterlife.co...sp?prod_id=8904


5. Phyllantus amarus, the Ayurvedic herb.

http://www.ncbi.nlm....t_uids=12425959

http://betterlife.co...p?prod_id=20475


6. Oregano oil.

http://www.ncbi.nlm....t_uids=15161188


7. Melissa officinalis, the lemon balm.

http://www.ncbi.nlm....t_uids=14233461


8. Rosemary, mainly due to its carnosic acid content.

http://www.ncbi.nlm....st_uids=8655093

http://www.ncbi.nlm....st_uids=8229021

Edited by tham, 21 October 2005 - 03:12 AM.

I have been able to acquire Tamiflu, but as enigma mentioned, the "cytokine storm" is a real, deadly danger. Has anyone been able to find supps that can mitigate cytokine production somewhat? I assume that one doesn't want to majorly reduce the action of the cytokines, just reduce enough to not kill you but still kill the virus.

Chris

Well, after a little (and I mean little), it looks like some folks are thinking statins could be useful for treating a cytokine storm.

Correct me if I'm wrong, but wouldn't treating yourself with Tamiflu within a day or two of infection -- reduce the severity of a cytokine storm?

I would think so if the Tamiflu has worked and reduced the viral load to a degree that your immune system does not initiate this "storm" in the first place. I am not a doctor though, and sometimes wish I had less interest than I do.

Chris

Pentoxifylline (Trental), a methylxanthine, is one
of the most versatile drugs in my opinion, largely
due to its abililty to inhibit TNF-alpha, IL-1 and IL-6.
Some studies show it has no effect on IL-1 though.

It is normally prescribed for intermittent claudication
and bed sores. The standard dosage for these
ailments is 400 mg three times daily.

It has been used with some success in infantile
sepsis, but appears to be less effective in adult sepsis.

http://www.ncbi.nlm....t_uids=14502367

http://www.ncbi.nlm....t_uids=14584009

http://www.ncbi.nlm....t_uids=10321674

http://www.ncbi.nlm....t_uids=10816353

http://www.ncbi.nlm....st_uids=9438767


I give pentoxifylline to support my father's congestive
heart failure :

1. It improves ejection fraction.

2. TNF-alpha, IL-1 and IL-6 are involved in the
apoptosis of myoctyes in heart failure and cardiomyopathy.

3. It inhibits cachexia (body wasting), a characteristic
of heart failure, aging and wasting diseases like HIV
and cancer, largely due to the blockade of these
cytokines. Pentoxifylline has also been studied in
the cachexia of cancer and HIV.

4. It slows down osteoporosis, which is accelerated
in heart failure.

http://www.ncbi.nlm....t_uids=11113392



The other drug which outperforms pentoxifylline
against inflammatory cytokines is thalidomide, but
that is of course unavailable.

Nettle leaf extract also inhibits TNF-alpha, IL-1 and
IL-6, but I am unsure of the dosage, and there are
hardly any studies on it in this respect.

http://www.ncbi.nlm....st_uids=8967906

http://www.ncbi.nlm....t_uids=15338166


Fish oil and GLA are supposed to inhibit the production
of inflammatory cytokines, rather than at the receptor
stage.

Edited by tham, 23 October 2005 - 04:57 PM.

Quercetin also has antiviral activity :

http://www.ncbi.nlm....t_uids=16019982

http://www.ncbi.nlm....t_uids=15359113

http://www.ncbi.nlm....t_uids=15668926


Apigenin, luteolin and chrysin has cytokine suppresive
activity :

http://www.ncbi.nlm....t_uids=15627476

Edited by tham, 27 October 2005 - 08:33 AM.

I seem to remember apigenin and luteolin mentioned in context of Bacopa M., as well. Maybe I'm just misremembering. Wouldn't be the first time.

Where do I get the true Echinacea that is truly the right species and taken from the right parts of the plant, which is guaranteed etc. Do you know of any brands which you can trust?

This looks like a pretty good product.

The arabinogalactans from larch tree extract actually
outperform echinacea as an immune booster.

The three species of echinacea commonly used
are purpurea, augustifolia and pallida.

http://www.thegoodea.....binogalactan

Edited by tham, 14 March 2006 - 03:45 PM.

I forgot all about selenium, which should
have been the first nutrient to consider.

http://www.texastech...entBirdFlu.html

I corresponded with Dr Julian Spallholz recently and
asked him about one of his research papers on
sodium selenite and cancer.

Selenium, or rather its deficiency in our
soil and diet, is also apparently responsible for
mutations of the SARS and Coxsackie viruses,
and probably a lot other RNA viruses. It also
inhibits, genetically and immunologically, HIV.
The research on this is complex and most of it
was done by Dr Will Taylor of Georgia University.

I did call Dr Taylor a couple of years ago. He told
me that at the time of the Coxsackie virus outbreak
in East Malaysia a few years ago, he faxed a lot of
his research papers over to the Malaysian Health
Ministry, but they ignored him. This didn't really
surprise me, as the Health Minister at that time
was actually a lawyer.

http://health.benabr...behind_tod.html

http://www.ncbi.nlm....t_uids=12615534

http://www.ncbi.nlm....t_uids=15050105

http://www.ncbi.nlm....t_uids=15465747

http://www.ncbi.nlm....t_uids=12730444

http://www.ncbi.nlm....st_uids=9152513

http://www.ncbi.nlm....t_uids=10554520

http://www.ncbi.nlm....t_uids=10535520

Edited by tham, 11 November 2005 - 02:32 PM.

Dr Will Taylor also told me that researchers from China
who were experienced with the use of sodium selenite
in treating Keshan's disease (caused by Coxsackie B5),
offered their help to the Malaysian health authorities
during the above outbreak, but were ignored as well.
Apparently these idiots couldn't believe that a nutrient
could possibly fight viruses.


http://www.whale.to/m/selenium.html

http://www.truehealth.org/break16.html

http://www.ncbi.nlm....t_uids=11878751



And this herbal combination looks like a really powerful
virus fighter :

http://betterlife.co...sp?prod_id=5883

Edited by tham, 11 November 2005 - 02:35 PM.

The Phyllanthus species appear to be quite potent
antiviral plants. Phyllanthus amarus (also known as
as Phyllanthus niruri, I think) in particular has activity
against HIV, which, like H5N1, is an RNA virus.

It also has activity against DNA viruses - HBV and HSV.
One of the flavonoids responsible for its antiviral action
appears to be ellagic acid.


http://www.ncbi.nlm....t_uids=12742578

http://www.ncbi.nlm....t_uids=16237706

http://www.ncbi.nlm....t_uids=15498604

http://www.ncbi.nlm....st_uids=1283310

http://www.ncbi.nlm....t_uids=16118024

http://www.ncbi.nlm....t_uids=15617349

http://www.ncbi.nlm....t_uids=14515028

http://www.ncbi.nlm....t_uids=13680841

http://www.ncbi.nlm....t_uids=12748977

http://www.ncbi.nlm....t_uids=12741619



http://www.cfsn.com/chanca.html

http://betterlife.co...p?prod_id=20475

Edited by tham, 23 August 2006 - 09:34 AM.

This is a good link appropriate to your question.
The supplement of choice mentioned here for
inhibiting the cytokine storm appears to be curcumin.

Combining this with resveratrol, which inhibits
neuraminidase, appears to be a one-two punch.

http://www.med-owl.c...us-Therapy.html


Curcumin is poorly absorbed. Taking it with Bioperine,
quercetin and bromelain would improve absorption.
There was a link giving the optimum protocol for taking
curcumin, but I forgot to bookmark it. Dr's Best has
a curcumin product combined with Bioperine.

http://betterlife.co...sp?prod_id=6160

http://www.naturalph...ts/curcumin-500

Edited by tham, 15 December 2005 - 01:24 PM.

Look into colloidal silver. You can make it yourself, after you learn how to do it right and get the right equipment. Then you can make gallons of it for pennies. Or you can look into a commercial product like Sovereign Silver. Its expensive, but it works well. Yahoo has a great users group for colloidal silver users . I use it, and so do countless others throughout the world. Look into it..do a Google.
Colloidal silver is being discussed in all the alternative medicine forums as a front line defense against avian flu. I have my supply ready, thats for sure!

Curcumin is poorly absorbed. Taking it with Bioperine,
quercetin and bromelain would improve absorption.
There was a link giving the optimum protocol for taking
curcumin, but I forgot to bookmark it. Dr's Best has
a curcumin product combined with Bioperine.

eeeks, bioperine aka piperine enchances the bioavalilability by inhibiting enzymes that fight environmental toxins. As a result, for example [1]:

"piperine was found to promote DNA damage and cytotoxicity induced by benzo[a]pyrene (B[a]P [a carcinogenic compound formed as a result of incomplete combustion of organic materials, found in engine exhaust, coal-, oil-, and wood-burning stove emissions, poorly-tuned furnaces, cigarette smoke, industrial soot, charred foods, incinerators, coke ovens, and asphalt processing, and secondarily in contaminated drinking water] in cultured V-79 lung fibroblast cells ... due to mechanisms that decrease the activities of [the detoxification enzymes] GST [glutathione S-transferase] and UDP-GTase [uridine diphosphate glucuronyl transferase] and increase the formation of a B[a]P-DNA adduct.”

I would not take supplements carrying that.

1. Chu CY, Chang JP, Wang CJ. Modulatory effect of piperine on
benzo[a]pyrene cytotoxicity and DNA adduct formation in V-79 lung
fibroblast cells. Food Chem Toxicol. 1994 Apr;32(4):373-7.

I have finally found the link on optimum protocols for
taking curcumin :

http://www.delano.co...nhancement.html

eeeks, bioperine aka piperine enchances the bioavalilability by inhibiting enzymes that fight environmental toxins.

Most supplement products which use Bioperine to enhance
absorption, such as those by Kal, add in miniscule amounts,
typically 5 to 10 mg, 20 mg at most, per tablet or capsule.

http://betterlife.co...sp?prod_id=7689

http://betterlife.co...sp?prod_id=7696


Piperine has also powerful antioxidant and anticancer properties :


http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

http://www.ncbi.nlm....l=pubmed_docsum

Also, a local doctor told me that echineachia doesn't "fight" viruses, it just triggers the immune system to get prepared for any unwanted invaders. I haven't read enough myself to know the exact effects of echineachia.

For once, your doc is right.
One of the common mistakes is to take echinacea when you have already caught a cold. It should be used all the season to strenghten the immune system.

I would not take supplements carrying [bioperine].

I avoid them too. I take so much stuff that I would not risk the chance that the blood serum concentration of something is overdosed.
Stacking Quercetin with Curcumin seems more interesting and safe. But I need to learn more about sulfotransferase.

(http://www.delano.co...nhancement.html)

The best resource I know of with information on which foods and herbs block neuraminidase yet suppress the cytokines TNF-a and IL-6 (ones that Bird Flu is immune and cause a cytokine storm) is here http://www.bird-flu-...-antivirals.htm

Just take 10-20 grams of Lactoferrin daily.

All Right I already take many supplements per day.
Does taking many supplements and performing lots of exercise make the body immune?

(like if the body is strong, is this body unit stronger against disease and infection?)

Doubtful. Exercise and supplements may enhance one's immune response, but I don't think that enhancement is likely to prevent one from contracting a contagious disease, although it may decrease the likelihood of illness or possibly reduce the severity of the course of the infection. I certainly wouldn't bank upon "immunity" from them.

Doubtful. Exercise and supplements may enhance one's immune response, but I don't think that enhancement is likely to prevent one from contracting a contagious disease, although it may decrease the likelihood of illness or possibly reduce the severity of the course of the infection.  I certainly wouldn't bank upon "immunity" from them.

______________________________________

NADH - Adenine Dinucleotide

Also called Co-E1

Package states:

NADH is biological Rocket Fuel.

Improves Cellular Energy
Elevates Mental Clarity
Cell Regeneration
DNA Repair
Boosts Immune System
A Potent Antioxidant

NADH is a coenzyme, antioxidant form of Vitamin B3

_________________________________________

I'm taking one with my AM RSV dose as a Chaser to boost immunity system.
Fight that Flu body!

WE'LL SEE?

NADH generates extracellular superoxide, so it might be as bad for you as "rocket fuel".

Biochem J. 1996 Sep 15;318 ( Pt 3):805-12.
High rates of extracellular superoxide generation by cultured human fibroblasts: involvement of a lipid-metabolizing enzyme.
O'Donnell VB, Azzi A.
Institute of Biochemistry and Molecular Biology, Bern, Switzerland.

Expression of NADPH oxidase and low superoxide generation (approx. 0.06 nmol/min per 10(6) cells) by cytokine- or ionophore-stimulated human fibroblasts is known. However, we here show that these cells also contain an ectoplasmic enzyme, distinct from NADPH oxidase, which can generate superoxide (2.19 +/- 0.14 nmol/min per 10(6) cells) at levels similar to phorbol ester-stimulated monocytes on exogenous NADH addition. Superoxide generation was temperature-dependent, insensitive to chelation (desferal), and had a K(m) (app)(NADH) of 11.5 microM. Inhibitor studies showed that there was no involvement of NADPH oxidase (diphenylene iodonium, diphenyl iodonium), prostaglandin H synthase (indomethacin), xanthine oxidase (allopurinol), cytochrome P-450 (metyrapone) or mitochondrial respiration (rotenone, antimycin A). NAD+ was a competitive inhibitor, whereas NADPH supported 40% of the rate seen with NADH. No luminescence was observed after the addition of lactate, malate, pyruvate, GSH or L-cysteine. NADH-stimulated superoxide generation was enhanced by the addition of (3-30 microM) arachidonic acid, linoleic acid or (5S)-hydroxyeicosatetraenoic acid [(5S)-HETE] but not palmitic acid, (15S)-hydroperoxyeicosatetraenoic acid [(15S)-HPETE], (15S)-HETE or (12S)-HETE. Several features suggest involvement of an enzyme related to 15-lipoxygenase, and, in support of this, we show superoxide generation and NADH oxidation by recombinant rabbit reticulocyte 15-lipoxygenase. The large amounts of superoxide measured suggest that the fibroblast extracellular enzyme could be a major source of reactive oxygen species after tissue damage.

PMID: 8836123

NADH generates extracellular superoxide, so it might be as bad for you as "rocket fuel".

"Several features suggest involvement of an enzyme related to 15-lipoxygenase, and, in support of this, we show superoxide generation and NADH oxidation by recombinant rabbit reticulocyte 15-lipoxygenase. The large amounts of superoxide measured suggest that the fibroblast extracellular enzyme could be a major source of reactive oxygen species after tissue damage."

Ur study did not test NADH 10 milligrams with RSV 1 gram on people.

They introduced allopurinol which may create vegetation in a petrie environment.
Allopurinol is some nasty stuff.
I'm no lab rat or rabbit cell, but, the NADH chased w. RSV made me feel very well.

Edited by bixbyte, 04 November 2007 - 11:14 PM.

Hey guys,

About the curcumin, you may not have noticed, LEF released a new one, that has
up to 7 times more absorption, doesn't contain piperine, and performs 6 times as well as the one with piperine. Higher blood levels, sooner, for longer.


I am taking it myself right now for a test ride, it's great. Doesn't make you smell like curry like the last one either.

http://www.lef.org/n.../item00407.html

http://search.lef.or...x...S curcumin

Click HERE to rent this advertising spot for SUPPLEMENTS (in thread) to support LongeCity (this will replace the google ad above).

Ur study did not test NADH 10 milligrams with RSV 1 gram on people.

So? (And would it kill you to type "your"?)

They introduced allopurinol which may create vegetation in a petrie environment.
Allopurinol is some nasty stuff.

By my reading of the abstract, they only used it in one or more of the inhibitor studies. Aubrey's read the whole paper and recommends against NADH supplementation.

I'm no lab rat or rabbit cell, but, the NADH chased w. RSV made me feel very well.

So will pure oxygen or meth. Your reasoning is pathetic. It seems to me that your time would be better spent on coloring books than posting in this forum.