33 replies to this topic

[dannov]

I've been looking into how to acquire my own Resveratrol 99% pharm. grade powder for a good price, as well as how to cap these for personal use. I came upon abatra.com, and contacted a sales rep for pricing. Including DHL S&H, the prices were as follows:

250g: CIF air total US$517 by DHL (door to door)
200g: CIF air total US$460 by DHL (door to door)
300g: CIF air total US$580 by DHL (door to door)
350g: CIF air total US$660 by DHL (door to door)
400g: CIF air total US$735 by DHL (door to door)
450g: CIF air total US$805 by DHL (door to door)
500g: CIF air total US$868 by DHL (door to door)

I just said that I'm a small personal seller. To put things in perspective, at 2g of Trans-Res a day, it'll last you 250 days...over 3/4 of a year. Not too shabby.

Anywho, at 250g the price per gram is $2.07/g, and at 500g the price is $1.74/g. If you have a friend or decent amount of money to spend, it's a pretty reasonable way to go. As for capsuling, I found a pretty high-quality capsule machine and empty-cap selling site in:

http://www.capsuline...x.php/cPath/201

I'm probably going with the 15 pill one due to pricing, and I guess it comes with 1000 empty caps. I heard veggie caps were the way to go, though I'm not sure what the different cap sizes mean (0, 000, etc.).

I'm personally sorta excited about capping my own products as I get to maintain my own standard for quality control while also saving money and having the sense of personal accomplishment in creating my own supplement. There may be better manufacturers out there for Res99 prices in wholesale, but that's the one that I've been looking at.

Feel free to share others and any experiences people may have had with capping their own products.

[Anthony_Loera]

'Capping' is a nice way to save money.

No issues here with it, and we recommend it to folks who are limited on resources.

It all really comes down to the quality of the powder again though... (doesn't it always?)

A

[quarter]

Why cap? I thought I read that the 98/99% powder was virtually tasteless, or at least not unpleasant.

[Anthony_Loera]

Good point quarter!

[dannov]

Ya, I was just worried about the Resveratrol possibly losing its effectiveness upon getting opened in whatever box that they supply me with. I'm not even sure that it is possible for Res to really degrade (haven't seen anything for or against it).

And ya Anthony, I have a real tight budget and that budget is engorged with your basic bodybuilding supplements and a couple select health/hair supplements on top of food...so I'm the type of guy that is looking to cut every corner that I can to still be able to get the nutrients that I need. =/

Also Anthony, how can one check the quality of the Resveratrol powder? Are there certain things to look out for in the powder profiles?

[Anthony_Loera]

dannov,

over the counter stuff in the usa usually has an expiration date, and the amount of rsv on the label. The makers (manufacturers) are supposed to abide by that, as the FDA will check the label against the contents. With the ephedra issue sometime ago, many makers didn't check the quality and consequently their labels were completely worthless to the consumer... some folks had bad reactions, and there were some deaths.

Having said that... folks like megaresveratrol sell 50% powder which is pretty reliable if your trying to cut corners. We sell the 99% powder, but it is more expensive. so, if you are cutting corners I recommend going to...

'Megaresveratrol.com' (what? RevGenetics is recommending mega? what just happened here?)

Yes, their 50% powder is pretty low in price, and will help you out. We simply don't sell it ourselves... I have spoken to the owner of Mega (we were going to do business sometime ago...) and he is a good guy. If you are looking for capsules, or 99% stuff, drop me a line.

Now if you want say... 5 kilos of 50% for personal use or more... then I can refer you to a third person, but PM me on that one.

thanks
Anthony Loera

[dannov]

Very cool, thank you Anthony!

[lhobbs1]

What the heck does CIF mean?

[Anthony_Loera]

From:
http://www.exportbur...dictionary.html

C.I.F.
Cost, Insurance, and Freight. A pricing term under which the seller pays all expenses involved in the placing of merchandise on board a carrier and in addition prepays the freight and insures the goods to an agreed destination.

Usually it arrives at an international port where you (or someone) can arrange to pick it up after all the fun-tastic paperwork is resolved... unless the shipper takes care of the paperwork ahead of time... I believe "door to door" usually means that they do.

[luminous]

Why cap? I thought I read that the 98/99% powder was virtually tasteless, or at least not unpleasant.

That reminds me. My Country Life resveratrol that I just got in the mail smells (and tastes?) a lot like burnt shoe polish. Does this mean it's rancid or is that normal?

[quarter]

I would guess thats normal. I once opened one of my country life capsules into my mouth and the stuff was horrible. But the country life stuff is 50% extract which doesn't taste good while the 98 or 99% stuff is supposed to be tasteless or at least not significantly unpleasant (I have not tasted this myself though).

[tintinet]

Synthetic 99%+ pure trans-resveratrol, IME, is practically taste-free. I can mix it with almost anything without altering the flavor of whateever it's mixed with.

The 98% extract t-resv. I've tried varies. Some has very minimal flavor; other preparations have a stronger flavor (and not one I particularly enjoy).

I haven't tried 99% extract, yet.

[maxwatt]

I would guess thats normal. I once opened one of my country life capsules into my mouth and the stuff was horrible. But the country life stuff is 50% extract which doesn't taste good while the 98 or 99% stuff is supposed to be tasteless or at least not significantly unpleasant (I have not tasted this myself though).

99% extract tastes just like 98% extract to me: not much taste at all. There may be some people who can detect a difference, or to whom 98% extract has a bitter taste. I know one person who went to great trouble to get 99% extract (from a different source than mine) but found it to have a strong laxative effect, unlike a 98% extract we both used. He did have the 99% tested, so what caused the reaction I do not know.

The taste of 50% extracts depends on the quality of the extract. A good quality, low emodin extract (such as RevGenetic uses) tastes slightly bitter, has a faint vegetable smell. Such a strong odor as you describe could be from solvent residue from the extraction process. A good quality product would be subject to two additional washing steps to remove such residues. It could also be due to other substances in the capsule. Doesn't Country Life have other things besides resveratrol extract?

[quarter]

Yeah, the country life 'resveratrol plus' also has: grape seed extract, grape skin extract and pine bark extract. I am aware that grape seed extract does not taste good so that could be the culprit.

But since its in a capsule the taste is of little significance, of more significance to me is that it seems to have no noticeable effects. Could still be doing me good on the quiet though.

[tintinet]

Several people using very high purity t-resv. haven't noticed any effects, either.

[maxwatt]

Several people using very high purity t-resv. haven't noticed any effects, either.

It may be the dos, or ones age and afflictions. I did not see maor reversal of my arthritic symptoms until I upped my dose from 500 mg twice a day, to 1.5 grams at one time. las may I subsequently upped the dose to 2 grams in he morning, one gram in the evening. the 1st metatarsal joint on my right foot is visibly smaller, I can wear shoes comfortably that didn't fit then. Two of three arthritic nodules on my toes have disappeared, and a third, the largest, continues to shrink. There seems to be a threshold beforetis effect kicked in. maybe lower doses would have prevented the disease, maybe not. I can't tell. But it takes a whopping amount to reverse it.

As an aside, I tried m\a\taking quercetin to see if I could get more "bang" from my resveratrol. After three days the arthriic pain grew worse. I stopped the quercetin, the pain was gone in a day. IMO, quercetin may increase the amount of resveratrol in the blood by blocking its sulfonation, but quercetin metabolites block the sirtuin activation of resveratrol.

If you are young and healthy, you might not have any aches and pains to fix.

[quarter]

Hmmm. All makes me wonder.

I was hoping for the endurance enhancing effects those little mice got and that some users have anecdotally reported, but not me. I'm not overly technical when it comes to this stuff, do you reckon the endurance effect noted by the mice et al. was due to the SIRT1 activation or by having resveratrol in the blood.

[health_nutty]

Several people using very high purity t-resv. haven't noticed any effects, either.

It may be the dos, or ones age and afflictions. I did not see maor reversal of my arthritic symptoms until I upped my dose from 500 mg twice a day, to 1.5 grams at one time. las may I subsequently upped the dose to 2 grams in he morning, one gram in the evening. the 1st metatarsal joint on my right foot is visibly smaller, I can wear shoes comfortably that didn't fit then. Two of three arthritic nodules on my toes have disappeared, and a third, the largest, continues to shrink. There seems to be a threshold beforetis effect kicked in. maybe lower doses would have prevented the disease, maybe not. I can't tell. But it takes a whopping amount to reverse it.

As an aside, I tried m\a\taking quercetin to see if I could get more "bang" from my resveratrol. After three days the arthriic pain grew worse. I stopped the quercetin, the pain was gone in a day. IMO, quercetin may increase the amount of resveratrol in the blood by blocking its sulfonation, but quercetin metabolites block the sirtuin activation of resveratrol.

If you are young and healthy, you might not have any aches and pains to fix.

Very, very interesting! I think I'm going to dump the quercetin. How much quercetin were you taking anyways?

[maxwatt]

Very, very interesting!  I think I'm going to dump the quercetin.  How much quercetin were you taking anyways?

I was taking 250 mg quercetin per 1 gram resveratrol.

I was hoping for the endurance enhancing effects those little mice got and that some users have anecdotally reported, but not me. I'm not overly technical when it comes to this stuff, do you reckon the endurance effect noted by the mice et al. was due to the SIRT1 activation or by having resveratrol in the blood.

I think the endurance is due to increased number and size of mitochondria, which is probably due to SirT3 activation, T3 being a mitochondrial Sirtuin gene. I noticed enhanced endurance at 500mg/day, but I have a yard-stick in my cycling activities: Heart Rate, Wattage, fixed length course and time. The improvement was perhaps 5 to 10% on wattage, which might not be enough to notice in everyday activities. Age, too, is a factor. I'm happy my performance is approaching what it was when I was in my forties.

The improvement in arthritis I noted is probably due to resveratrol's effect on NF-kappa. I don't know if this is Sirtuin mediated, or if it is another mechanism that is involved. Anyone?

[health_nutty]

Thanks again maxwatt. Your toe is an invaluable resource here at imminst

[kenj]

^^^^ ha ha, excellent.

From a 99% extract I've noticed not much. The 50% extracts clearly disturbed my mood, not fun.
One possible effect from 99%, at least combined with 2x500mg metformin: a stronger appetite suppression, as others here have noted.
Favorable gene-expression changes, "somewhat mimicking" CR? Anyhoo; restriction of calories, which is core for me, comes much easier with this combo.

[maxwatt]

Thanks again maxwatt.  Your toe is an invaluable resource here at imminst

Before, May 15, 2007: Taking 350 mg/day to 500 mg twice a day since Jan 1, 2007. Pain decreased but no change in swelling, or deformity.
SEE BEFORE IMAGE HERE


After, Aug 12, 2007 From May 15, increased dose to 1000 mg once per day, the 1500, then http://health.ph.gro...b=2&m=s&o=02000 mg once per day, every month.
SEE AFTER IMAGE HERE

Not clearly visible due to cell phone camera resolution, arthritic nodules on 1st and 2nd toe are gone. Arthritic nodule on thrd toe is greatly reduced in size, continuing to shrink. I can wear shoes again that had ceased to fit, and the big toe bends now without pain. Makes walking a lot easier, especially baefoot.

I had these posted earlier, but bandwidth issues forced me to remove the pictures (like I'd have to pay for it.) Also, using yahoo groups images can't be done directly with imminst's software due to formatting issues.

(Some PUNishment directed at health nutty: this is proof that resveratrol cures Tolio. In also cures Kneasles. But you need Viagra to cure SmallCox.)

Edited by maxwatt, 26 August 2007 - 02:55 AM.

[krillin]

The improvement in arthritis I noted is probably due to resveratrol's effect on NF-kappa.  I don't know if this is Sirtuin mediated, or if it is another mechanism that is involved.  Anyone?

J Biol Chem. 2005 Dec 2;280(48):40364-74.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L.
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.

Accumulating evidence suggests that neurodegeneration induced by pathogenic proteins depends on contributions from surrounding glia. Here we demonstrate that NF-kappaB signaling in microglia is critically involved in neuronal death induced by amyloid-beta (Abeta) peptides, which are widely presumed to cause Alzheimer disease. Constitutive inhibition of NF-kappaB signaling in microglia by expression of the nondegradable IkappaBalpha superrepressor blocked neurotoxicity, indicating a pivotal role for microglial NF-kappaB signaling in mediating Abeta toxicity. Stimulation of microglia with Abeta increased acetylation of RelA/p65 at lysine 310, which regulates the NF-kappaB pathway. Overexpression of SIRT1 deacetylase and the addition of the SIRT1 agonist resveratrol markedly reduced NF-kappaB signaling stimulated by Abeta and had strong neuroprotective effects. Our results support a glial loop hypothesis by demonstrating a critical role for microglial NF-kappaB signaling in Abeta-dependent neurodegeneration. They also implicate SIRT1 in this pathway and highlight the therapeutic potential of resveratrol and other sirtuin-activating compounds in Alzheimer disease.

PMID: 16183991

[maxwatt]

The improvement in arthritis I noted is probably due to resveratrol's effect on NF-kappa.  I don't know if this is Sirtuin mediated, or if it is another mechanism that is involved.  Anyone?

J Biol Chem. 2005 Dec 2;280(48):40364-74.
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L.
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA.
(....snip)
PMID: 16183991

And resveratrol treats arthritis in rabbits by inhibiting NF-kappaB

Inflammation. 2007 Apr;30(1-2):1-6. Links
Effects of resveratrol in inflammatory arthritis.Elmali N, Baysal O, Harma A, Esenkaya I, Mizrak B.
Department of Orthopaedics and Traumatology, Inönü University Medical Faculty, 44069 Malatya, Turkey. nelmali@hotmail.com

Nuclear factor kappa B (NF-kappaB), is a pivotal transcription factor involved in the activation of the TNF-alpha and IL-1beta genes. Activation of NF-kappaB in synovial cells is a feature seen in arthritis patients. Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation. We aimed to determine the in vivo effects of intra-articular injections of resveratrol on cartilage and synovium in an experimental rabbit inflammatory arthritis model. MATERIALS AND METHODS: Arthritis was induced by intra-articular injection of three times of 50 mug lipopolysaccharide (LPS) at day 0, 4 and 8 at 4-day intervals into the knee joints of rabbits. To the test group, 10 muMol/kg resveratrol in the DMSO was injected in the knees at day 0 and then it was continued once daily for 2 weeks. To the control group the same time and amount of DMSO was injected the knees of rabbits. All rabbits were killed 1 week after the last injection and cartilage tissue and synovium were evaluated with semiquantitative scoring histologically. RESULTS: According to control group in the resveratrol group, significantly decreased cartilage destruction was determined by H&E staining (p = 0.04). Loss of matrix proteoglycan content in the cartilage was much lower, as determined by safranin O staining (p = 0.03). We also observed marked synovial inflammation after intra-articular injection to control knees, but not in the resveratrol treated group knees (p = 0.01). CONCLUSION: This study suggests that intra-articular injection of resveratrol may protect cartilage against the development of experimentally induced IA.

PMID: 17115116

[health_nutty]

(Some PUNishment directed at health nutty: this is proof that resveratrol cures Tolio.  In also cures Kneasles.  But you need Viagra to cure SmallCox.)

Lol!

[dannov]

LoL ya, I got that Smallcox comment too. Gold.

[jeromeaparis]

That reminds me.  My Country Life resveratrol that I just got in the mail smells (and tastes?) a lot like burnt shoe polish. 
Does this mean it's rancid or is that normal?

Hi,

After using with succes since two weeks
Nature's Way resveratrol, (37,5mg tr-resveratrol / caps)
with Gingkio Biloba extract Tanakan

I received today Country Life resveratrol (100mg tr-resveratrol / caps)

I worry a lot with the strong smell of burn or smoke (like in a chimney)
coming from the opened can.
If I open a cap, and smell, it is realy a very strong odor that stays in my nose
for half an hour.

I am non smoker and never eat burned food.

Nature's way opened caps smell is very neutral.

both brands include 50% resveratrol, grape seed extract

component that is in in country life and not in N'way
is Pine bark extract, maybe the smell comes from it .... ?

Jerome (Paris, France)

[dannov]

If it's 50% Res, you're never entirely sure what the other 50% is.

[jeromeaparis]

I wrote to " Country Life " to explain the problem of strong smell of smoke - burn
of their " resveratrol plus "

They answer me: " It is a natural odor stemming from the ingredient knotweed. It is safe to use. "

I realy doubt, cause my Resveratrol from " Nature's Way " has absolutly no smell like that.

Jerome

[dannov]

Natural to their Res I guess, hah.