17 replies to this topic

[shuffleup]

There is a product supplying Ubiquinol which is supposed to be a highly available Q10. Anyone tried this product?

[eternalone]

Who is it from? Also important thing to look for is that it does NOT contain Titanium Dioxide, as it has been implicated in increasing arterial plaques. On that note..I've seen Q10 with Silicon Dioxide. Is this a safe alternative? Anyone know?

[shuffleup]

Who is it from? 

Made by Life Extension.

Other ingredients: canola oil, diglyceryl monooleate, gelatin, glycerin, lecithin, beeswax, purified water, caramel color.

[niner]

Also important thing to look for is that it does NOT contain Titanium Dioxide, as it has been implicated in increasing arterial plaques.

I've heard warnings about TiO2 in this forum in the past, but from a quick search of pubmed I haven't found any evidence of danger from oral consumption of TiO2. The only exception was if the TiO2 was in the form of nanoparticles such as are used in the new transparent TiO2 sunscreens. This site has a pretty good treatment of the topic: http://www.organicma...niumdioxide.asp

What is the evidence that TiO2 in tablets is harmful?

[shifter]

I have a naturally fermented q10 thats in a phosphate base (dry powder NOT in oil)

Here is some info about the product
http://www.alternati...oduct/coq10.htm if looking at price keep in mind its in Australian currency

for the lazy, here is the info (I have taken the info about what q10 does as we already know).

Warning: Less than 4% of Q10 products sold use natural fermented Q10 (made from special algae in Japan) - most products are made using synthesised Q10 made by mixing vitamins and minerals together, or from an extract from the tobacco plant!

(do not take Q10 while on Warfarin therapy without medical advice)

Advance Q10 - now available in: 30mg; 50mg and high strength 100mg.

Gel or Powder?

It takes nine months to produce naturally fermented Q10. Q10 is oxidised by light, heat and liquid, so it must be kept dry before use. Q10 packaged in glass bottles or gel, such as oil based delivery systems, will have already started to oxidise!

How Much Food To Produce 30mg Q10?

Try 2.7kg of eel; 1.3kg sesame seeds; 14.2kg eggplant; 10.3kg soya beans; 2.1kg almonds or 750g of organ meat! The average Q10 content in Western diets is less than 5mg per day



SO, YOU THINK ALL Q10 IS THE SAME?

By John O'Neill  (John is the managing director of Advance Nutrition. With his many years of practical experience with the testing of numerous brands of Coenzyme Q10 both local and overseas, he may be regarded as the world's foremost authority on CoQ10 brand testing.
He is the author of a highly revealing book on energy production, 'Breaking the Sound Barrier of Human Energy Potential'. Though his book, John is trying to tell all fitness aspirants, athletes, bodybuilders and other health enthusiasts, the safe and yet effective way of attaining their goal in the fitness arena without the danger of long-term permanent bodily injury.)

Seventeen years spent testing about 100 different Coenzyme Q10 (Ubiquinone, Ubidecaronene) formulations, attempting to improve absorption, delivery and efficiency of Coenzyme Q10 into the aerobic energy systems within human cells (mitochondria) has been my overwhelming "passion of life."

Good fermented (natural) CoQ10 powder, along with careful laboratory handling should in dry capsule form deliver immediate (one minute) results in short- term tested efficiency. It should also give on going subtle health improvements year after year. This fact is known to me because one has documented consistent personal physical improvements in endurance and strength since including quality produced Coenzyme Q10 in my diet over the last 11 years, a complete change from the downward spiralling direction previously.
I've been involved personally with approximately 30,000 aerobic human efficiency tests on the subject of Coenzyme Q10 alone in the last 17 years entailing a broad spectrum of 91 different worldwide brands of CoQ10 using them as a comparison standard with our own locally (Australian) produced product. Some of these brands were tested 40 times to ascertain accuracy.

Facts that emerged during testing showed that soft gel, oil-based delivery CoQ10 formulations do exhibit increased blood plasma levels of CoQ10. However, it also showed high urine excretion rates of CoQ10! The CoQ10 delivery system that we use (phosphate-based) does not show high levels of CoQ10 excretion in urine even after massive doses are administered.
The system we use is far superior because it (CoQ10) is absorbed within seconds into surrounding arteries and muscles. It does not keep circulating in the blood, and to kidneys which automatically recognize the fact that it (CoQ10) is far above normal levels and is therefore excreted in the urine.

Coenzyme Q10 belongs, stores and is used by cellular mitochondria (aerobic system of cells). The quicker it is delivered to mitochondrial sites. the less is lost. and increased efficiency is gained.

We have tested 26 soft gel oil-based delivery CoQl0 with unbiased arbitrators overseeing testing procedures. Most of these soft get oil-based delivery preparations did produce some varying physical improvement efficiencies. The best was an American life extension formula which consistently gave 30% increase in efficiency only, according to milligrams of CoQ10 used compared with our local (Australian) product over a week long test. Some brands delivered zero efficiency readings even when subjects were given 225 - 450 milligrams of CoQ10 per day.

Modern pharmacology at this point in time worldwide demands blood plasma level of CoQ10 as evidence of cellular delivery. But in our experience, oils and fats drastically inhibit the amount of CoQ10 that can be absorbed through mitochondrial membranes where it is essentially used for efficient aerobic energy production. The fact is evident by treadmill and ergometer testing in human subjects conducted by myself in the presence of impartial judges. During the last 17 years, modern medicine can detect most essential nutrients in our blood plasma and generally that is a guide indicating cellular absorption of nutrients. But this is not always the truth.

There is only one real test that is foolproof in terms of body cell nutrient absorption and consequent physical improvements. This occurs when subjects are subjected to work-rate, heart-rate evaluations under physical load. With top quality CoQ10. 98% of people will show increased efficiencies under workload once CoQ10 is administered. The remaining 2% will generally respond within one week. Never have I recorded one case history with any subject using our CoQ10 where there has been no improvement given time. This statement is made with the aid of 30,000 separate stress tests concerning CoQ10 research.
Unfortunately, modern medicine has not yet managed to see or understand exactly what occurs within the mitochondria in respect to behaviour of the atoms of 84 elements that we use in our cells to create energy in the quest for survival.

Even our best microscopes would have to improve their magnification capacity by some 15 times to see an atom of hydrogen at work in the mitochondria.
The movement of hydrogen and oxygen atoms within the mitochondria is the major factor contributing to low toxic aerobic energy production necessary for health and survival.

Good quality CoQ10 contains a massive molecular structure of active hydrogen. It is my humble learning experience that the hype surrounding soft gel, oil-based delivery of CoQ10 does not stand up when faced with the human physical testing evidence with either short term or long term in terms of CoQ10 potentials. If it did, I would use oil-based delivery formulae.

It is yet another case of "Let The Buyer Beware!"

The quality of Coenzyme Q 10 varies greatly from supplier to supplier so select carefully.

As far as I know the LEF product is in an oil base and clamins to be 8 times more absorbable than normal? Which normal? the cheapie ones you find for a few dollars on a supermaket shelf with no cofactors to help absorption? Or other more expensive brands and in a powder form? And I would hate to excrete it all in my urine if thats what the oil based products do...

Does anyone know how is the LEF one made? Is it Naturally Fermented or from tobacco leaves or synthetic?

Also is there any difference in the naming of the q10 eg Ubiquinol or Ubidecarenone?


At the moment I am taking 50mg per day of the product I have shown in the link. Considering how much food it takes to get 30mg of q10 in a diet I figure 50mg is enough for a healthy mid 20's guy.

[shuffleup]

As far as I know the LEF product is in an oil base and clamins to be 8 times more absorbable than normal? Which normal? the cheapie ones you find for a few dollars on a supermaket shelf with no cofactors to help absorption? Or other more expensive brands and in a powder form? And I would hate to excrete it all in my urine if thats what the oil based products do...

Does anyone know how is the LEF one made? Is it Naturally Fermented or from tobacco leaves or synthetic?

Also is there any difference in the naming of the q10 eg Ubiquinol or Ubidecarenone?

Here's a thread about it on M&M...
http://www.mindandmu...08&hl=ubiquinol

QUOTE
When it comes to achieving optimal results from your CoQ10 supplement, how much you absorb is of critical importance. Since 1983, Life Extension has continuously sought out the purest, most bioavailable CoQ10 available. Now, Japan's largest CoQ10 producer has patented a form of CoQ10 that offers unprecedented bioavailability—capable of increasing human blood levels up to 8 times more efficiently than the higher-absorption CoQ10 products on the market today.

In studies from Japan, this superior new form of CoQ10 has shown remarkable antiaging effects. In one study, it was 40 percent more effective than conventional CoQ10 in slowing markers of aging in middle-aged mice.1 In a study of aged rats, this new form of CoQ10 demonstrated anti-fatigue effects that were 2.5 times greater than conventional CoQ10 supplements.2

The reason this new form of CoQ10 is so effective is that scientists have succeeded for the first time in producing a stabilized ubiquinol capsule form of CoQ10. While CoQ10 exists in both ubiquinol and ubiquinone forms, the ubiquinol form has been shown to be vastly more bioavailable than conventional ubiquinone CoQ10. In a study measuring absorption in humans supplementing with 150 mg and 300 mg , far lower doses of ubiquinol CoQ10 produced blood plasma levels of CoQ10 that were equivalent to those produced by much higher doses of ubiquinone.3 In fact, it would take up to 8 times more ubiquinone than ubiquinol to raise CoQ10 blood levels to the same level.3

Each capsule of Super BioActive CoQ10 Ubiquinol provides 50 mg of this novel ubiquinol form of CoQ10. With its superior absorption and ability to remain bioavailable over much longer periods of time,1 most healthy people will need to take just one capsule twice daily to obtain significantly higher blood levels of CoQ10.

References
1. Exp Gerontol 2006 Feb;41(2):130-40.
2. Kaneka Corporation study. Treadmill test with the age rat at the age of 61-63 weeks. 2006
3. Regul Toxicol Pharmacol. 2006 Aug 17; Absorption Comparison Using Different Form of CoQ10.

[shifter]

Thanks for that. I believe the LEF product to be all it says but want to know also why they chose an oil based delievery system and if the q10 is naturally fermented or synthetic.

The fermented one I take also originates from Japan so maybe the same thing? But my one says Ubidecarenone and not Ubiquinol.

How does Ubidecarenone rate in the scheme of things?

[niner]

BAC has 50 grams of ubidecarenone for $95. It's from Kaneka, the company that makes ubiquinol. Compared to the buck-a-day LEF ubiquinol, the powder from BAC is a hell of a deal, but how does it compare in terms of bioactivity? Anyone have a clue?

[sentrysnipe]

Is it better than Idebenone?

[shadowrun]

I've been creating a regular CoQ10 Skin Cream - (works insanely well)

I wonder if anyone knows or could conjecture if a switch to Idebenone or Ubiquinol would show an improvement...at least in the topical sense

[niteinnyc]

I've been creating a regular CoQ10 Skin Cream - (works insanely well)

I wonder if anyone knows or could conjecture if a switch to Idebenone or Ubiquinol would show an improvement...at least in the topical sense

Two companies that use natural CoQ10 from Japan, and which have been used in research studies are Healthy Origins & Tischon Corp. Healthy Origins suspends the CoQ10 in olive oil liquid gels. Tischon Corporation Q-gel, suspends the CoQ10 in a hydrosoluble liquid gel (please note that there is soy in this one) available from Epic4Health. Tischon Corp Q-gel has been FDA approved for therapeutic use.

There is some info on Idebenone from the viewpoint of ICQA here:
http://www.icqa.org/ICQA/HomePage.html

Here are some skin care products with Ubiquinol by Tischon Corp. which they claim to be hydrosoluble.
http://www.skinsosmooth.com/

Tischon's liquid form of Ubiquinol, 1,000mg per fluid ounce x 16.9 $129.95
http://www.epic4heal...coasubsufa.html

Healthy Origins CoQ10 400mg x 60 $75.99 Natural Ubiquinone from Japan
http://www.healthyor...duct_Code=35027

Some basic info on CoQ10:
http://www.nutrilear...oq10/coq10.html


Where do you get your cream and what are the effects?

Edited by niteinnyc, 08 April 2007 - 07:23 PM.

[krillin]

As far as I know the LEF product is in an oil base and clamins to be 8 times more absorbable than normal?

According to LEF's article, the absorption advantage is all over the place. At 100 mg, it's 1.6 times better. At higher doses it's 8 times better. 1200 mg ubiquinone = 150 mg ubiquinol. 2400 mg ubiquinone = 300 mg ubiquinol.

http://www.lef.org/m...rt_coq10_01.htm

In my experience, 50 mg of ubiquinol ($17.55/month) is no better than 90 mg of Puritan's Pride ubiquinone ($6.07/month) at improving gum health and distance running, so the 1.6 factor seems reasonable.

[kenj]

In my experience, 50 mg of ubiquinol ($17.55/month) is no better than 90 mg of Puritan's Pride ubiquinone ($6.07/month) at improving gum health and distance running, so the 1.6 factor seems reasonable.

Curious if you or anyone have tried 200mg/day ubiquinol, over a longer period, and any difference noted? The article is promising, and, yeah, - they sell it.

[DukeNukem]

I have been taking 150mg/day of ubiquinol (LEF). I do not notice any benefit. But then, I'm already in good shape for my age.

[kenj]

But then, I'm already in good shape for my age.

No kiddin'. Thx.
Still, perhaps I need to age a little more, to get into the 150mg+ Ubiquinol Club...

[shifter]

Jarrow sells a 100mg version of Ubiquniol. Looks rather good and cheaper per mg (you do get less capsules per bottle though)

http://www.iherb.com...s&cid=ubiquinol

[kenj]

I started on a cap of Jarrow's, as soon as it came out (was taking the regular CoQ10), - this is a powerful product for cellular energy and whatnot; - following a few days with increasingly daytime energy (without being "hyper"), I carried this ample energy right into bed: No sleep! (I usually sleep 7/h), so I have to cycle this one. I think it potentiates many other sups as well.

[peterson]

Ubiquinol gives me a nice long lasting mild energy lift at 100 mg.