17 replies to this topic

[stretch]

Hello everyone. This is my first post and I'm so happy that I found this exciting place.

I'm currently taking 10mg of selegiline (brand name Jumex) per day in order to treat my prolactin level that is at the high end of the normal range. I have taken it for two weeks now and have noticed somewhat elevated selfconfidence but nothing else yet.

My question is that as deprenyl may have some MAO-A inhibiting effect and I read on "500mg of trans-resveratrol per day" thread that also resveratrol acts as MAOI, are they safe to combine or should one be concerned about excess tyramine or possible seratonin syndrome?

I wonder if anyone here would have a link to a paper that discusses the MAOI effects of resveratrol?

[edward]

A couple of questions. First have you gotten an MRI? If your prolactin is on the high end of normal you might very well have a prolactinoma (prolactin secreting tumor, usually around the pituitary gland). Secondly, why such a high dosage of deprenyl/selegiline? 10 mg is very very high especially just to simply stimulate dopamine, thus reducing prolactin levels. I assume you are doing this under the care of a physician.

[luv2increase]

Hello everyone. This is my first post and I'm so happy that I found this exciting place.

I'm currently taking 10mg of selegiline (brand name Jumex) per day in order to treat my prolactin level that is at the high end of the normal range. I have taken it for two weeks now and have noticed somewhat elevated selfconfidence but nothing else yet.

My question is that as deprenyl may have some MAO-A inhibiting effect and I read on "500mg of trans-resveratrol per day" thread that also resveratrol acts as MAOI, are they safe to combine or should one be concerned about excess tyramine or possible seratonin syndrome?

I wonder if anyone here would have a link to a paper that discusses the MAOI effects of resveratrol?

Deprenyl only has MAO-A inhibiting action when used in a higher dose. Using it at 10mg a day won't inhibit MAO-A. You will be fine with combining them.

[stretch]

Edward, my physician thought that since my prolactin is still in the normal range there is no need for an MRI. I'm probably going to get it checked later anyway in order to catch any kind abnormality early and of course it would be nice to own pictures of your brain. The problem is that if I had a prolactin secreting microadenoma, I would not want to treat it with cabergoline (standard treatment). Autoapoptosis occurs on proliferated prolactin secreting cells after women's breastfeeding period but it may take some time before we learn to induce it in prolactinomas.

I stopped deprenyl for now as I read an user experience saying that it flattens emotions. Several publications in pubmed support that by showing that deprenyl seems to blunt the “cocaine high".

Has anyone noticed a change in their emotionality from using resveratrol?

[edward]

I agree with luv2increase, from what I have read you would have to be close to a 20mg dose per day to start to inhibit MAO-A significantly so 10mg should be ok, however it is high if all you are trying to do is raise dopamine, between 1 mg and 5 mg per day should be sufficient as it takes about a week for your body to build back MAO-B levels from just one dose of deprenyl.

As far as resveratrol is concerned I have noticed an increase in energy and mood, supposedly resveratrol does inhibit MAO both A and B and acts as a SNRI (serontonin and norepinephrine re-uptake inhibitor). Anecdotally, I have been taking prozac for depression for years and I have lowered my dosage due to the effects of resveratrol, my doctor agreed that this is a good idea.

I don't see any problem taking deprenyl and resveratrol together, nor do I think anyone has reported any classic MAOI problems (hypertensive crisis etc.) with resveratrol so it appears as though the MAOI effects of resveratrol are mild.

[bert]

Taking deprenyl and an SNRI can result in the so-called "serontonin syndrome" and may result in death. I'm wondering where you found the info on resveratrol being an SNRI. Ive been trying to find a reliable source on this. Can you help?

[oregon]

I have been taking prozac for depression for years

edward, I suggest you to take Tryptofan instead. I personally think that Prozac would be a thing of the past if Tryptofan was in free sale in the US. FDA first banned due to political reasons, but I believe that now you can get a prescription for it (I have to check this).

Who else thinks that the company behind Prozac would go bankrupt if Tryptofan was available over-the-counter in US?

[medievil]

"Who else thinks that the company behind Prozac would go bankrupt if Tryptofan was available over-the-counter in US?"

huh? prozac is way more effective then tryptofan

[edward]

I've tried tryptophan and 5Htp and they both make me extremely sleepy. No one is making money off Prozac these days since the patent is expired. A months supply only costs me about $4.00 from Walmart! Thats without even using my insurance.

[oregon]

I've tried tryptophan and 5Htp and they both make me extremely sleepy. No one is making money off Prozac these days since the patent is expired. A months supply only costs me about $4.00 from Walmart! Thats without even using my insurance.

I do not fully agree with you on this issue. People do make money on Prozac. Brand name Prozac costs a little bit more:
http://www.drugstore...0502&trx=1Z5006

However, what upsets me is this:
http://www.timesonli...icle1784993.ece

I wonder if any doctor could just say: take fish oil, B-complex, and exercise (and/or tryptofan), instead of prescribing artificial SRIs.

Lack of B-vitamins and Omega 3s has been linked to depression (not lack of Prozac).

Edited by oregon, 16 May 2007 - 07:55 AM.

[medievil]

i'm srry but above suggestion is not as effective as prozac if i beleive all anecdotal reports on the dr.bob site

it does help tough, and i do agree that some cases dont need prozac

[edward]

My rant about alternative depression treatments:

I am going to say this once and get it out of my system. First off I am a huge believer in alternative treatments, supplementation and a healthy lifestyle and anyone who has read my posts on here can attest to that. I have supplemented a whole host of the most popular supplements all my life (including many that supposedly help with mood) and have actively exercised between 3 and 7 days a week since about the age of 12 yet I still developed clinical depression, so bad that I was hospitalized at age 17 (even while exercising and supplementing). Antidepressants saved my life and continue to be a part of my of my daily routine even now over ten years later. I have tried to go off them for months at a time while trying St. John's Wort, SAMe and other supposed treatments. (While still exercising and taking the latest supplements as I have for most of my life) These alternative treatments simply did not work. I find it very disturbing when I read about people (who obviously have never had clinical depression or a medical degree of any sort) try to give advice to people about ditching antidepressants in favor of alternative treatments. Suicide (the end result of untreated or mistreated depression) is no joke, been there almost did that. If any of you have read my posts I am a huge believer in alternative, nutritional and complimentary medicine (see my successful herbal treatment for low testosterone compared to Testim Gel thread along with the lab results). That being said though, there is a place for modern medicine and in this case I have ample personal experience. If you have clinical depression you need antidepressants and therapy. Yes exercise, nutrition and a whole host of supplements are helpful but without pharmaceutical help the prognosis is not very good at least if you are dead set on going the alternative route get a Physician or Naturopath or someone qualified in some way to monitor your progress and be a safety net.

Alright I'm done.

[oregon]

Of course there are "snake oil" natural treatments, but what I wrote is based on scientific research and documented facts.

I heard that long term usage of Prozac has very nasty side effects. It can be due to the not recycled serotonin.
http://www.rxlist.co.../fluoxetine.htm (Prozac has been linked to suicides when used by children)
http://www.prolibert...er/20010407.htm

Therefore I wrote that boosting serotonin levels using precursors and co-factors is safer (tryptophan and B vitamins).

I am sorry that you cannot stop Prozac now. I would guess it changed your brain chemistry.

I had lots of problems in life but I was able to go though them without becoming significantly depressed. I am just curious, did you take B-complex, Omega-3's and/or tryptophan before you were on the brink of suicide?

Good luck!

Edited by oregon, 17 May 2007 - 03:13 AM.

[edward]

Yes I tried all three (ordered tryptophan from Europe as it was banned at the time in the US) along with good nutrition and exercise along with many other supplements all prior to my severe episode of depression.

[luv2increase]

Yes I tried all three (ordered tryptophan from Europe as it was banned at the time in the US) along with good nutrition and exercise along with many other supplements all prior to my severe episode of depression.

Many things can cause depression. It doesn't necessarily have to be a chemical imbalance of the mood neurotransmitters of the brain. It could be stemmed from a "nurture" cause. Maybe something negative happened to you in your childhood that results in your depression. You could be sub-consciously suppressing these traumatic events etc.. and not even know it. Go to emofree.com and read more about the whole thing is you'd like.

[medievil]

a chemical imbalance is a stupid idea that never has been proven, depression is complex, hence even botox seems to work

[graatch]

Edward, you should of course consider that long-term use of SSRI drugs will result in neurotransmitter re-regulation, making life without them much more difficult until further re-regulation occurs.

> a chemical imbalance is a stupid idea that never has been proven

Hm? All mental activity reflects chemical activity, and vice versa, a feedback loop. Therefore, a "balanced" state being subjectively attributed, depression very well reflects chemical imbalance.

[meatwad]

(spam) (spam) (spam)

Thanks random chinese seller.

I don't think "Deprenyl" mixes with anything.
I would have been better off never buying/using that stuff.
I'll keep my opinion to myself though, if you think it makes everything great than go ahead and eat it.