57 replies to this topic

[VictorBjoerk]

And it explained a lot, But CR maybe only would make push your lifespan to 110 or so instead of 85-90,although that's a lot,130-140 years sounds a bit too much and Roy Walfords guesses of 150-160 just can't be realistic........To do that real anti-aging therapies would have to come......

[Matt]

I agree, I think most CRONies starting in their 20's will reach anywhere from 95-115 or so. But who knows right, the question probably won't resolved because by then we'll likely have better methods of slowing down or reversing aging. Anyway here is a comparison shot of two mice same age, one on CR and one not. Similar things can be seen in the fur from CR vs Ad lib monkey pictures too. Since the CR group generally look better at least we can say if CR doesn't extent our lives, we'll at least look a bit younger haha :D

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[Dmitri]

Matt, can you go ahead and create a pill for me to be able to get the benefits of CR without doing what you are doing?

Thanks, I expect it by lunch tomorrow. )

Didn't someone post a thread a few weeks ago that mentioned resveratrol mimicking CR effects?

[Dmitri]

Interesting thread but I still have some doubts; we have seen that in controlled laboratory (artificial) settings CR can extend life in animals but humans lives are not as simple or artificial. It’ll be interesting to see how well people who are on a CR diet fair in the next 10-20 years, especially the couple who’s in their 60s (the authors of The CR Way). They'd be better case studies instead of 20 year old Cronies we have here since it's not difficult for non-CRONIES to look good at 40 or 50.

[Matt]

Dmitri, you don't believe humans will stay looking younger on CR when it's already proving to be the case in Mice, Rats, Dogs, Monkeys etc...? I have to say, my biggest worry about lifelong CR is risk of infection related mortality. Seriously, there needs to be some better work done in this area.

Another 10 years for Paul and Meredith and we'll see how they are then. I think they look good for their age relative to what I see here in Wales. But it's a shame some start so late when all the greying, wrinkled skin, and other signs of aging are well established. Our oldest CRONies are now in their mid 70s to mid 80's I believe. A guy named Don doesn't look all that bad for his age, he seems more younger when I seen him on the walters show (live to 150).

Edited by Matt, 01 October 2008 - 04:28 AM.

[VictorBjoerk]

Dmitri, you don't believe humans will stay looking younger on CR when it's already proving to be the case in Mice, Rats, Dogs, Monkeys etc...? I have to say, my biggest worry about lifelong CR is risk of infection related mortality. Seriously, there needs to be some better work done in this area.

Another 10 years for Paul and Meredith and we'll see how they are then. I think they look good for their age relative to what I see here in Wales. But it's a shame some start so late when all the greying, wrinkled skin, and other signs of aging are well established. Our oldest CRONies are now in their mid 70s to mid 80's I believe. A guy named Don doesn't look all that bad for his age, he seems more younger when I seen him on the walters show (live to 150).

I think the couple Paul and Meredith only have been doing CR for 14 years so of course they don't look as young as you potentially could do if you started CR in your 20's.

Anyhow they look better than most overweight saggy people in their 60's with diabetes and atherosclerosis as well as other ailments.

Regarding wrinkles and grey hair, Would you really delay the greying of your hair in humans? I mean greying is not a disease connected to other aspects of aging. You don't have to have a certain amount of "damage" to get grey hair.

Wrinkles

Dmitri, you don't believe humans will stay looking younger on CR when it's already proving to be the case in Mice, Rats, Dogs, Monkeys etc...? I have to say, my biggest worry about lifelong CR is risk of infection related mortality. Seriously, there needs to be some better work done in this area.

Another 10 years for Paul and Meredith and we'll see how they are then. I think they look good for their age relative to what I see here in Wales. But it's a shame some start so late when all the greying, wrinkled skin, and other signs of aging are well established. Our oldest CRONies are now in their mid 70s to mid 80's I believe. A guy named Don doesn't look all that bad for his age, he seems more younger when I seen him on the walters show (live to 150).

I think the couple Paul and Meredith only have been doing CR for 14 years so of course they don't look as young as you potentially could do if you started CR in your 20's.

Anyhow they look better than most overweight saggy people in their 60's with diabetes and atherosclerosis as well as other ailments.

Regarding wrinkles and grey hair, Would you really delay the greying of your hair in humans? I mean greying is not a disease connected to other aspects of aging. You don't have to have a certain amount of "damage" to get grey hair.

Wrinkles are strongly connected to exposure to UV- light and not necessary that much with aging.

Edited by Shonghow, 01 October 2008 - 09:49 AM.

[Matt]

I think the couple Paul and Meredith only have been doing CR for 14 years so of course they don't look as young as you potentially could do if you started CR in your 20's.

Yeah I know...

Regarding wrinkles and grey hair, Would you really delay the greying of your hair in humans? I mean greying is not a disease connected to other aspects of aging. You don't have to have a certain amount of "damage" to get grey hair.

Absolutely YES! As I just mentioned the greying of the fur on Rhesus Monkeys, Rats, Mice, and dogs have all been delayed or prevented by calorie restriction. This has been know for so long! Greying either is genetic or associated with *aging* yes.
http://www.longlivey...althyYears.aspx

"In addition, according to observations of the researchers, the control dogs exhibited more visible signs of aging, such as graying muzzles, impaired gaits and reduced activity, at an earlier age than the lean-fed dogs."

Wrinkles are strongly connected to exposure to UV- light and not necessary that much with aging.

http://www.imminst.o...showtopic=22516

read the full paper.

I would imagine that CR in humans exposed to light would cause less damage and skin aging than an ad lib person.

Edited by Matt, 01 October 2008 - 02:52 PM.

[Matt]

Heres one guy from the CR conference talking a bit about how young CRONies look when he met them
http://video.google....6...29903&hl=en

He starts mentioning it around 9 MINUTES into the video.

[VictorBjoerk]

Regarding greying, Some people get grey her in their teens without showing accelerated aging in other ways.
Therefore my sceptism in humans.(I know the monkey pictures showed delayed greying)

Yes Michael Rae looks freakishly young for being almost 40 he started CR at 28-29 or something didn't he?

[Matt]

Regarding greying, Some people get grey her in their teens without showing accelerated aging in other ways.
Therefore my sceptism in humans.(I know the monkey pictures showed delayed greying)

Yes of course greying doesn't mean accelerating aging, but what's your point? Greying is still a sign of aging, generally speaking. It isn't like that's the only evidence for increased lifespan in animals on CR though is it? Even among human that become centenarians look younger at all stages of their life, they keep their hair colour, most who are not heavily exposed to the sun basically have less wrinkles etc... The carers of these Rhesus monkeys will tell you (and they're all under the same enviromental conditions) that the CR group generally look younger. I'm sure they are better able to tell than us if this is true. Apparently it is. You're really skeptical it will work at all?

In the description from the article here it states
1. http://www.nytimes.c...NG_GRAPHIC.html (PICTURE)
2. http://www.nytimes.c...ion/31agin.html

1. CANTO 25
Although a senior citizen -- the average rhesus monkey lifespan in captivity is 27 -- Catno is aging fairly well. Outwardly, he has a nice coat, elastic skin, a smooth gait, upright posture and an energetic demeanor. His bloodwork shows he is as healthy as he looks"

OWEN 26
He gets more food, but Owen isn't aging as well. His posture has been affected by arthritis. His skin is wrinkled and his hair is falling out. Owen is frail and moves slowly. His bloodwork shows unhealthy levels of glucose and trigclycerides.

2. (main article)

"In a laboratory at the Wisconsin National Primate Research Center, Matthias is learning about time’s caprice the hard way. At 28, getting on for a rhesus monkey, Matthias is losing his hair, lugging a paunch and getting a face full of wrinkles. Yet in the cage next to his, gleefully hooting at strangers, one of Matthias’s lab mates, Rudy, is the picture of monkey vitality, although he is slightly older. Thin and feisty, Rudy stops grooming his smooth coat just long enough to pirouette toward a proffered piece of fruit. Tempted with the same treat, Matthias rises wearily and extends a frail hand. “You can really see the difference,” said Dr. Ricki Colman, an associate scientist at the center who cares for the animals. "

Yes Michael Rae looks freakishly young for being almost 40 he started CR at 28-29 or something didn't he?

I would guess hes been on CR for about 9 years + now. I don't know, maybe he can tell us! Yeah I think he looks the same age as my friends who are around my age lol.

Edited by Matt, 01 October 2008 - 08:53 PM.

[Matt]

From article: http://www.jsonline.....aspx?id=415837

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[Dmitri]

Regarding greying, Some people get grey her in their teens without showing accelerated aging in other ways.
Therefore my sceptism in humans.(I know the monkey pictures showed delayed greying)

Yes Michael Rae looks freakishly young for being almost 40 he started CR at 28-29 or something didn't he?

There are plenty of people I know who are almost 40 yet they look like they're in their mid to late 20s and their not on CR. This is why I would like to see how Meredith Looks in 10-20 years; if she hasn’t aged much then I will believe.

[Matt]

some people say that you look older when you lose weight, I don't think this is always true. I have a comparison picture here (and make sure you read the post I made too) of what I was like BEFORE I went on Calorie Restriction. Most people who know me think I look younger now than when I did even at 17 years of age. I explained linked a possible mechanism for this in my post, but I don't really know.
http://www.matts-cr.blogspot.com/

[Ben]

Staying skinny can in itself help to keep you looking younger. I think that people associate thinness with youth and if they see that you are skinny would be probably more likely to think that you are young. Being overweight I personally connect with being middle aged.

[Dmitri]

some people say that you look older when you lose weight, I don't think this is always true. I have a comparison picture here (and make sure you read the post I made too) of what I was like BEFORE I went on Calorie Restriction. Most people who know me think I look younger now than when I did even at 17 years of age. I explained linked a possible mechanism for this in my post, but I don't really know.
http://www.matts-cr.blogspot.com/

I have a question about CR? Are there any studies that show whether or not we get benefits from CR by only practicing it 3 or 4 days out of the week? I'm asking because that's what I seem to be doing at the moment. I have a lot of homework now so I only have time to exercise 3-4 days a week on those days I consume about 2,200-2,600 calories. However, on days in which I don't exercise I only consume about 1,500-1,900 calories which can be considered CR.

[Matt]

Another comparison shot

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Edited by Matt, 20 December 2008 - 07:23 PM.

[Matt]

New Comparison shots from the rhesus monkey study at wisconsin. Click on them for more detail. The results just visually as well statistically in terms of deaths looks significant.

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•  cr_monkeys.jpg   173.55KB   73 downloads

Edited by Matt, 09 July 2009 - 07:52 PM.

[becomingwiser]

Matt, you've convinced me than slim rhesus monkeys look better than overweight ones.

I also usually find slim humans to be the most attractive.

[Matt]

Some new pictures from the researchers. Worth zooming into the faces of the first picture, very high quality and you can obviously see big differences in how old each monkey looks. Canto who is 28 (which is around 81 human years) still looks like a very young rhesus monkey.

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•  monkey_diet_study09_5641.jpg   1.4MB   31 downloads
•  monkey_diet_study09_5713.jpg   1.97MB   25 downloads
•  monkey_diet_study09_5719.jpg   1.73MB   21 downloads

Edited by Matt, 29 July 2009 - 02:39 PM.

[Matt]

If you want to stay looking young [whether or not it extends maximum lifespan], CR clearly has poweful effect on how OLD one looks as they age. This has been obvious with all other animals tested not just in monkeys. Canto shows a much more aged appearance in this photo, canto still looks like a very young rhesus monkey

NORMAL DIET



CALORIE RESTRICTION DIET

Edited by Matt, 29 July 2009 - 02:45 PM.

[kismet]

Clearly those other monkeys are fat, dontcha see? Great pics.

Edited by kismet, 29 July 2009 - 03:04 PM.

[Matt]

It's interesting that advice from a study not long ago said that in order to stay looking younger you should WEIGHT MORE. It was a twin study...

Not all the monkeys are likely to be fat in the study by the way, they all have different weights of course lol.

Edited by Matt, 29 July 2009 - 03:17 PM.

[rollo]

If I looked like Michael Rae at 40, i would want to die... (no offense to Michael Rae)

6' tall and 115lbs?? wow, no thank you

wait till he's a little older and falls and breaks his bones cause he doesn't have any muscle mass to protect himself... i hope he stays in a lab type environment where he can be safe at all times....

[tunt01]

If I looked like Michael Rae at 40, i would want to die... (no offense to Michael Rae)

6' tall and 115lbs?? wow, no thank you

wait till he's a little older and falls and breaks his bones cause he doesn't have any muscle mass to protect himself... i hope he stays in a lab type environment where he can be safe at all times....

maybe he will be a pile of bones at age 40, though i think it will be doubtful given his focus on bone/bmd health. one thing i am pretty sure he wont be is an asshole.

[rollo]

If I looked like Michael Rae at 40, i would want to die... (no offense to Michael Rae)

6' tall and 115lbs?? wow, no thank you

wait till he's a little older and falls and breaks his bones cause he doesn't have any muscle mass to protect himself... i hope he stays in a lab type environment where he can be safe at all times....

maybe he will be a pile of bones at age 40, though i think it will be doubtful given his focus on bone/bmd health. one thing i am pretty sure he wont be is an asshole.

he is over 40 and he is a pile of bones...

wonder what his test levels are at...

better to be an asshole at 40 then to be a twig, flailing in the wind...

no offense to Michael Rae...

[Matt]

he is not over 40, and his tests at WUSTL were apparently very good, some of the best they've had on some tests... and to me he looks alright and looks young. Im sure hes doing alright, and he appreciate your concern, but stop it please, you're being silly.

[Skötkonung]

If I looked like Michael Rae at 40, i would want to die... (no offense to Michael Rae)

6' tall and 115lbs?? wow, no thank you

wait till he's a little older and falls and breaks his bones cause he doesn't have any muscle mass to protect himself... i hope he stays in a lab type environment where he can be safe at all times....

maybe he will be a pile of bones at age 40, though i think it will be doubtful given his focus on bone/bmd health. one thing i am pretty sure he wont be is an asshole.

he is over 40 and he is a pile of bones...

wonder what his test levels are at...

better to be an asshole at 40 then to be a twig, flailing in the wind...

no offense to Michael Rae...

Whatever happened to capital letters? Do you both have cheap keyboards that don't feature a SHIFT key? It is hard to take your posts serious when you both write in the style of high school girls.

Rollo, yeah he is skinny and looks emaciated, but so what? He is a longevity experiment and regardless of whether he succeeds or fails, the information he will provide to other longevity researchers will be beneficial to all of us.

Prophets and Matt, Michael is skinny and weak. Get over it. That is one of the drawbacks to CR. Emaciated or not, if CR does work, he can laugh at all of us non-CR people as we rot in our graves. I won't care, I probably won't be alive to be offended

Edited by Skotkonung, 30 November 2009 - 03:16 AM.

[niner]

no offense to Michael Rae...

No, nothing like that...