3 replies to this topic

[davie1a]

Having seen the CR and muscle loss videos showing a 69 year old man with a dam good physical shape (showing virtually no muscle loss) due to constant muscle training and exercise throughout his life then only to see it all go from the years of 69 - 79 even with training due to the ageing condition of Sarcopenia, I pose this question:

Do you think testosterone replacement, along with DHEA and other hormones could have stopped Sarcopenia from happening in the above case and in other men who train in the same way throughout life.

[curious_sle]

Maybe this helps... it refers to a specific protein beeing helpfull in sarcopenia

http://jp.physoc.org.../full/569/2/489

We tested the hypothesis that skeletal muscle ubiquitin–proteasome-dependent proteolysis is dysregulated in ageing in response to feeding. In Experiment 1 we measured rates of proteasome-dependent proteolysis in incubated muscles from 8- and 22-month-old rats, proteasome activities, and rates of ubiquitination, in the postprandial and postabsorptive states. Peptidase activities of the proteasome decreased in the postabsorptive state in 22-month-old rats compared with 8-month-old animals, while the rate of ubiquitination was not altered. Furthermore, the down-regulation of in vitro proteasome-dependent proteolysis that prevailed in the postprandial state in 8-month-old rats was defective in 22-month-old rats. Next, we tested the hypothesis that the ingestion of a 5% leucine-supplemented diet may correct this defect. Leucine supplementation restored the postprandial inhibition of in vitro proteasome-dependent proteolysis in 22-month-old animals, by down-regulating both rates of ubiquitination and proteasome activities. In Experiment 2, we verified that dietary leucine supplementation had long-lasting effects by comparing 8- and 22-month-old rats that were fed either a leucine-supplemented diet or an alanine-supplemented diet for 10 days. The inhibited in vitro proteolysis was maintained in the postprandial state in the 22-month-old rats fed the leucine-supplemented diet. Moreover, elevated mRNA levels for ubiquitin, 14-kDa ubiquitin-conjugating enzyme E2, and C2 and X subunits of the 20S proteasome that were characteristic of aged muscle were totally suppressed in 22-month-old animals chronically fed the leucine-supplemented diet, demonstrating an in vivo effect. Thus the defective postprandial down-regulation of in vitro proteasome-dependent proteolysis in 22-month-old rats was restored in animals chronically fed a leucine-supplemented diet.

(Received 2 September 2005; accepted after revision 26 September 2005; first published online 29 September 2005)
Corresponding author D. Attaix: INRA, Nutrition and Protein Metabolism Unit, 63122 Ceyrat, France. Email: attaix@clermont.inra.fr

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You might also want to read the following threads in sci.life-extension
http://groups.google...01e5fdfc315a129
http://groups.google...e252157bf1dde04

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Hope this helps

[davie1a]

Thanks curious!. Just what I need.

[curious_sle]

My pleasure