Beta blockers sometimes have depression as a side effect. It may also be because they block noradrenergic receptors that are involved in mood. Drugs that increase norepinephrine usually can improve mood, so if you block some of those receptors your mood could take a turn for the worst.
I defintely felt almost a dulling sense in my excitability, so for quite awhile it felt unnatural. But that was not really the problem, hypoglycemia was. I was prone to it before hand but whilst on metoprolorol I just couldn't stop the levels from dropping towards the end of the day. It messed with me in a huge way.
If anyone has suffered really bad hypoglycemia you'll know it starts off with the littlest of things ticking you off. This then progresses to a state of confusion, coordination becomes impaired (driving like someone who is mildly intoxicated) and a deep irritable scatteredness sets in. At times it feels like a really harsh MDMA come down, everything seems to annoy the shit out of you no matter how much you try to rationalise the situation. Also, your pupils become dilated the more your body's physical stress manifests itself. In the midst of all this your brain is getting damaged to a considerable (and I believe totally overlooked) extent.
I am still so surprised that today many physicians find "hypoglycemia" a debatable topic. Dumbarses...