maxwatt,
I believe this part of the presentation was intentionally ambiguous to help lead the horse to water. In slide 7, the ambiguous phrase "healthy lifespan" is used when referring to the 30% extension of lifespan in mice. Most would take away that this means the normal mice. However, it is actually referring to the mice on a high fat diet with resveratrol vs. those on a high fat diet without resveratrol. This was carefully qualified in slide 5 when explaining the survival curves of the HF groups in which the term "healthy lifespan" was used to describe the 30% increase in survival. Very sneaky.
Sinclair has not yet published the data from the normal mice, which has raised curiosity and suspicion in the scientific community. The consensus is that resveratrol likely had little or no effect on lifespan in the normal group. If this is true and the findings are published, then this could have a negative financial impact, especially at this stage in the game (pre/immediately post IPO and key investments). Therefore, one in this situation may want to delay the publication. In mice/rats, showing lifespan extension and/or an amelioration of the pathologies with a harmful diet has and can been demonstrated with a variety of nutrients (leucine, probiotics,etc). However, demonstrating lifespan extension with a normal diet has not been shown.
I'm one of the horses that was lead to RSV. I still have most of 1/2 kilo of 99%+ RSV. I hope it's shown to be a real LE elixir. But I'm a recovering wishful thinker. So when I listen to a Sirtris presentation my reaction is: show me published results (preferable in humans).
Sirtris people are claiming that SRT501 lowers glucose. Just in diabetics? What about in people that have fasting glucose in the 90s (mg/dL)? I never read in this forum that anybody had his/her glucose lowered by taking RSV.
It is also claimed that there are no known side effects. But some people in this forum reported IBS symptoms.
Somebody asked about the other sirtuins. The speaker sort of implied that Sirtris products could also upregulate other sirtuins. And mentioned a work by a Harvard group on the neural effects of SIRT2. Actually, that's a work by Kazantsev's group showing that INHIBITION of SIRT2 can protect against deterioration from Parkinson's disease (PMID: 17588900).