2 replies to this topic

[treonsverdery]

I read online that
The effectiveness of most anticancer drugs depends upon interfering with the synthesis of new DNA material. It is now well known that there are certain times of day in which DNA synthesis is either high or low. In order to maximize the effectiveness of these drugs it makes sense to administer them at a time when the synthesis of genetic material is at its height, since you will then catch most of the cancer cells with their DNA unzipped, as it were

this is called chronobiology

http://www.ncbi.nlm....tractPlusDrugs1 Chronopharmacokinetics have been shown for several cardiovascular active drugs (propranolol, nifedipine, verapamil, enalapril, isosorbide-5-mononitrate, digoxin, etc.). Far more drugs were shown to display significant daily variations in their effects (chronopharmacodynamics, chronotoxicology) even after chronic application or constant infusion. In conclusion, there is clear evidence that the dose/concentration-response relationship of drugs can be significantly dependent on the time of day. Thus, circadian time has to be taken into account as an important variable influencing a drug's pharmacokinetics and/or its effects or side effects

do people have ideas about longevity supplement dosing times that are beneficial perhaps resveratrol has a chonobiologic aspect

I'm aware that we all like the idea of keeping blood levels of supplements high

Edited by treonsverdery, 14 February 2008 - 01:26 AM.

[treonsverdery]

The paper had been published by Dr. Halberg in 1972 in the journal Science. This article concerned the use of a standard drug ARA-c, with which Dr. Hrushesky was already very familiar. Simply by changing the time of day at which the drug was given to leukemic mice, Prof. Halberg could increase their survival three-fold.
http://www.alkalizef...ronobiology.htm

At that time, Dr. Hrushesky and his NCI colleagues were "kicking drugs up the decision network tree for a twenty percent increased life span." Yet here was a way of increasing survival by 300 percent! It didn't involve anything other than materials that lay at hand, just an existing drug combined with good timing

[Hedgehog]

I read online that
The effectiveness of most anticancer drugs depends upon interfering with the synthesis of new DNA material. It is now well known that there are certain times of day in which DNA synthesis is either high or low. In order to maximize the effectiveness of these drugs it makes sense to administer them at a time when the synthesis of genetic material is at its height, since you will then catch most of the cancer cells with their DNA unzipped, as it were

this is called chronobiology

http://www.ncbi.nlm....tractPlusDrugs1 Chronopharmacokinetics have been shown for several cardiovascular active drugs (propranolol, nifedipine, verapamil, enalapril, isosorbide-5-mononitrate, digoxin, etc.). Far more drugs were shown to display significant daily variations in their effects (chronopharmacodynamics, chronotoxicology) even after chronic application or constant infusion. In conclusion, there is clear evidence that the dose/concentration-response relationship of drugs can be significantly dependent on the time of day. Thus, circadian time has to be taken into account as an important variable influencing a drug's pharmacokinetics and/or its effects or side effects

do people have ideas about longevity supplement dosing times that are beneficial perhaps resveratrol has a chonobiologic aspect

I'm aware that we all like the idea of keeping blood levels of supplements high

That is kinda like the HDAC inhibitors the play with the topology of the DNA. For example in a cancer cell often parts of the DNA tha need to be expressed (for apoptosis) are wound up very tight in DNA. Rendering some VEGF, EGFR...ect only effective for a short period of time. However, if you target the cell with a EGFR and HDAC at the same time it is like a double combo you stop the proliferation via EGFR but you also allow the DNA to be expressed that allows it to under go apoptosis. IMO cancer therapy is moving more into multi targeted therapy like the what is seen in the HIV market.

Edited by hedgehog_info, 14 February 2008 - 06:00 AM.