Hi Everyone,
I thought I would start this post to see if we can discuss some common beliefs about resveratrol, Below are some taken from a recent press release that I believe we mostly have discussed before. Maybe we can add more info about other beliefs as well.
So let's examine them!
-- Mice fed high-dose resveratrol did not live as long as mice fed a
plain standard calorie diet. Animals on the lower dose (360 milligram human
equivalent) lived longer than those on the higher dose (1565 mg) of
resveratrol. [Resveratrol Delays Age-Related Deterioration and Mimics
Transcriptional Aspects of Dietary Restriction without Extending Life Span.
Cell Metabolism 2008 Aug;8(2):157-68]
This one seems pretty good, what is left out, is that the mice on a low dose where fed an EOD (every other day) diet (out of convenience or costs, we are really not sure). But the fact is that folks could stop eating every other day, and maybe get the same results. However, the other item is that RSV might increase human average lifespan, possibly by reducing heart disease or by improving blood glucose disposal and insulin signaling in some people. The mice did not die of heart disease after all, while people do.
-- While researchers once advised consumers to wait for stronger
synthetic molecules that can stimulate the Sirtuin1 gene by 1000-fold or more,
actual studies with warm-blood mammals showed over-activation of the Sirtuin1
gene increases the occurrence of heart failure by more than 7.5 fold. [Sirt1
regulates aging and resistance to oxidative stress in the heart. Circulation
Research 2007; 100: 1512-21]
This is another common piece of misinformation.
The study mentioned simply did not use resveratrol to over-activate the Sirtuin1 gene. Resveratrol has never been recorded to provide that level of activation that would cause heart failure. Last but not least, the Sirtris drug that is "1000 times" more powerful than resveratrol, was given to mice and these did not have instant heart attacks. So, no, there has never been a mouse drop dead due to resveratrol.
-- While it was initially believed only mega-dose resveratrol would be
effective, and that strong Sirtuin1 gene activators would be required, a much
lower dose of resveratrol (100 milligrams human equivalent of trans
resveratrol, 4 to 320 times lower than previous studies, when provided in a
patent-applied for matrix of other small molecules), exerted a 9-fold greater
genomic effect than plain resveratrol or a calorie-restricted diet. In this
study, calorie restriction significantly differentiated (up or down-regulated)
198 genes, and resveratrol, its molecular mimic, significantly influenced 225
genes, while resveratrol-based matrix (Long******) significantly
differentiated 1711 genes. [Short-term consumption of a resveratrol-containing
nutraceutical mixture mimics gene expression of long-term caloric restriction
in mouse heart. Experimental Gerontology 2008 Sep;43(9):859-66]
This one is interesting, as it relies on additional ingredients to your regimen, not just resveratrol. It is known that mice and men have different metabolisms, so generally a human would take a greater dose than a mouse. For now, let's say that the dose calculations are right, what do we need to get this kind of benefit? Just like adding additional vitmains to your regimen, you can simply add Vitamin D3, IP6, and Quercitin (although in some studies this shows to lower SIRT1 activity) to your resveratrol regimen for the additional benefits.
Vitamin D3 (90 tablets) 1000ui can be bought for as low as $3.57
IP6 - (120 Capsules) 500mg can be bought for as low as $7.67
Quercetin - (180 Capsules) 250mg can be bought for as low as $9.26
Well, that would be it right? However, the author of this press release has a regimen of 300mg of micronized resveratrol: http://web.archive.o...;catagory=Tools
So it appears that 100mg is not enough for the Author of the press release, maybe 300mg of trans-resveratrol should be the minimum to consider.
Sardi says websites selling resveratrol supplements still parrot earlier
but now outdated news reports about Sirtuin1 genes and mega-doses appear
oblivious to the striking changes in resveratrol science that have been
recently published. "Paying heed to the current data now available, mega-dose
resveratrol is ill-advised and may be related to uncommon but reported side
effects, namely Achilles heel tendon inflammation, skin rash, joint
stiffening, flu-like symptoms and numbness in fingertips, all which are
reversible," says Sardi.
I believe we have read here in the forum, that most folks having issues with resveratrol (which is a total of 4-5 people here) generally take 50% resveratrol. There are no wide spread issues that we know of. If you are concerned, simply avoid 50% resveratrol products, and instead use 98% or 99% resveratrol products. People believe products that use 50% like Biofor** or Longevine** can cause issues because of other phytonutrients in the other 50% of the product that is not resveratrol.
Longe***** was formulated as an emulsified, stabilized, and
bioavailability-enhanced resveratrol supplement over four years ago and a
patent applied for in 2004. The 3rd generation Longe***** now features
micronized and microencapsulated trans resveratrol in a matrix of quercetin,
rice bran phytate, vitamin D3 and ferulic acid.
This product has switched from regular resveratrol (50% purity) to micronized resveratrol (still 50% purity). This simply means that this product has increased the dosage, not by adding more resveratrol to the product, but by increasing it's absorbability. In essence you maybe absorbing more of the product with micronized resveratrol. How much more?
Here is an example: The Author of this press release takes 300mg of micronized resveratrol. Using the animal study by Westphal (CEO of Sirtris) that was submitted in in USPTO document 20060292099, regarding regulr resveratrol comparision versus micronized resveratrol. The Author's dose of 300mg of micronized resveratrol, comes out to about 900mg of regular resveratrol.
900mg of Non-micronized Resveratrol might be considered a high dose by some, but apparently is ok for the author.
Does anyone want to add more interesting misnomers, beliefs about resveratrol or items to discuss?
A
