Low dose B2. One of the few supplements that can work as an abortive. Take 10 mg or less at a time.
B1 (HCL) and Biotin in a high dose as preventatives.
B1 requires a little bit of magnesium for optimal effectiveness. Take up to 2 grams of B1 (I like 1500 mg) and 5 mg of Biotin at a time.
You can probably go much higher on Biotin if you can get undiluted powder. There really isn't a toxicity limit. I've read studies of people taking up to 300 mg at a time.
You can take B1 and Biotin multiple times per day, if you want to, or just once.
I don't yet have experience with B5.
Niacin at an average dose as a preventative.
B12 and folate tend to make me worse when I have a migraine in progress. I'd assume that they aren't doing much as preventatives and possibly making me slightly more vulnerable.
The recommended essential B vitamin preventatives won't be perfect, but they will help and will have the mildest side effect profile of almost anything else you can supplement with. When you have a migraine issue, and thus need to rely on supplements or medications over a long term, the side effect profile and their continued effectiveness is important. The recommended B-vitamins most directly support cellular energy production; which is what is malfunctioning during a migraine.
Mitochondrial support: CQ10 and PQQ.
Last, a recent effective abortive I have found is the use of an acupressure mat in bed. It's painful, but it is one of the few things that works. Use it from anywhere from 10 minutes to one hour. The longer you use it, seemingly, the larger the body's response. In response, your body will essentially release the equivalent of a medium to strong injected painkiller. It's probably either dynorphin or upregulated Mu opioid reception. You will likely fall asleep after you use it, especially if you had a migraine. It's also great for fevers.
Natural abortives, like the above acupressure mat recommendation and the recommended B2, are precious unless you are into prescription abortives. The only OTC abortive that is effective for me is Excedrin, which is terrible for your liver/kidney health long term if you are taking it regularly.
I dislike ginger and curcumin as supplements for migraneurs because they make the immune system more active. That's generally a bad thing for us because the immune system is already overly active when a migraine hits, in our most valuable organ, putting neurons and other anatomy at risk. Memory and other processes are at stake and are vulnerable. Taking supplements that can further stimulate the immune system during an attack is not a good idea in my opinion. Besides that, I have only found these supplements to be mildly effective in prevention and non-effective to aggravating in aborting a migraine.
Edited by golgi1, 16 March 2016 - 05:02 AM.