15 replies to this topic

[numbered]

this is it

carnosine 1500mg
Metformin 400mg
coq10 800mg
benfotiamine 1000mg
P5P 200mg
r-lipoic 600mg
alcar 2000mg
vit D 6400iu
Taurine 3000mg
Vit C 5000mg
Biotin 3000mcg
B12 1000mcg
glucosamine 1500mg
Biosil
Multi vit ( 1000mg calcium in it)

I am about to start astragaloside iv . im gonna do 50mg for a month and then up the dose to 100mg. I'm gonna do a six month cycle on astragaloside iv.

[kismet]

Your regimen looks pretty random to me.

this is it

carnosine 1500mg
Metformin 400mg
coq10 800mg
benfotiamine 1000mg Are you sure you're not taking 100mg?  AFAIK No benefit was ever demonstrated at such high doses, side-effects or harm is likely; don't forget the possibly increased risk of cancer (which could be mitigated at extremely high doses, I'm not sure if 1000mg is enough if that is your plan, but it's a rather dangerous idea).
P5P 200mg
r-lipoic 600mg
alcar 2000mg
vit D 6400iu
Taurine 3000mg
Vit C 5000mg Why 5g? Why not more, not less? Studies, claims, ancedotal evidence?
Biotin 3000mcg
B12 1000mcg
glucosamine 1500mg What form, sulphate?
Biosil
Multi vit ( 1000mg calcium in it) please, be more specific. Don't forget calcium and vitamin D (but mostly high doses of calcium) could increase risk of kidney stones, in theory, such a high dose combination could even increase CVD risk, possibly via increased calcification. Consider vitamin K2 and slightly reducing vitamin D intake or cut out the calcium and regularly check blood levels.

I am about to start astragaloside iv . im gonna do 50mg for a month and then up the dose to 100mg. I'm gonna do a six month cycle on astragaloside iv.

Edited by kismet, 12 April 2009 - 12:32 AM.

[nameless]

800 mg of CoQ10 daily? Unless you have a mitochondrial type of problem there, why so much? And I do hope you are checking your D levels via blood testing. Most of your doses look way too high to me, but I tend to be conservative.

[rwac]

vit D 6400iu
Multi vit ( 1000mg calcium in it)

You're taking a lot of Calcium and vit D.
I hope you're getting an equal amount (1000mg) of Magnesium and atleast some K2 (MK-4 or MK-7).

[numbered]

vit D 6400iu
Multi vit ( 1000mg calcium in it)

You're taking a lot of Calcium and vit D.
I hope you're getting an equal amount (1000mg) of Magnesium and atleast some K2 (MK-4 or MK-7).

my 25OHD with 6400 is 54 ng/mL. dont get much sun at all.
benfo is indeed 100mg . mistyped it. it was late last night.
my mag intake is about 700mg
im taking 50mcg mk7 should i take more?
ive been experimenting with coq10 for a long time. after suffering from myocarditis summer 2005 .frequent afib and pvc's was what i was left with. coq10 at a high dose was the only thing that stopped them completely. gave me back the ability to exercise ,a normal ecg, no more chest pains , no more failing heart in general. my doc was amazed . he was against coq10 .

[numbered]

as for glucosamine , its glucosamine hcl . is that bad?
Vit C is the first supp i ever took . My mother is a supp advocate her self and she started me on a simple multi vit and half a gram of c when i was 12 or so. Never stopped since then. worked my dose up to 5 gr after the heart incident.never had a cold,flu , fever,whatever , since then. i think c helped a bit in that.

[kismet]

as for glucosamine , its glucosamine hcl . is that bad?

Yep, it's a waste of money. The only formulation that might work is the sulphate salt.
Why the taurine and b12? (yes, met reduces absorption but do you really need that much?)
Did you notice any (side-)effects with metformin? Did you know it could reduce testosterone levels and mess with your TSH levels? Have you done any hormone panels before and after starting treatment?

Edited by kismet, 12 April 2009 - 02:18 PM.

[numbered]

as for glucosamine , its glucosamine hcl . is that bad?

Yep, it's a waste of money. The only formulation that might work is the sulphate salt.
Why the taurine and b12? (yes, met reduces absorption but do you really need that much?)
Did you notice any (side-)effects with metformin? Did you know it could reduce testosterone levels and mess with your TSH levels? Have you done any hormone panels before and after starting treatment?

hm hm , guess ill order some glucosamine sulphate . Id rather stay this high a dose with b12 since i dont get any sides just to be safe with Metformin reducing b12. No sides from Metformin . I take blood tests every 6months Doc says everything normal. Ill adjust dosage if anything changes in my blood panel that might indicate damage. I take taurine for glycation benefits . fasting BS 73 A1c 4.2 last time i was checked. i am not on CR but im lean . my BMI is 19.2

[nameless]

You probably could try reducing your CoQ10 somewhat, based on symptoms. Usually after you saturate the body with a high dose, you don't have to remain on that dose forever -- but if it works for you, I won't say it's a bad thing.

You may want to get copper values tested, if you haven't already, due to the high dose vitamin C you are taking. Although I'm not entirely sure how accurate or what is the best way to get copper tested... I suppose hair or serum.

[nancyd]

vit D 6400iu
Multi vit ( 1000mg calcium in it)

You're taking a lot of Calcium and vit D.
I hope you're getting an equal amount (1000mg) of Magnesium and atleast some K2 (MK-4 or MK-7).

I thought 1000mg was an average dose; so I'm wondering what dose is recommended.

Edited by nancyd, 13 April 2009 - 12:36 AM.

[rwac]

my 25OHD with 6400 is 54 ng/mL. dont get much sun at all.
benfo is indeed 100mg . mistyped it. it was late last night.
my mag intake is about 700mg
im taking 50mcg mk7 should i take more?

I would reduce the calcium to say about 400 mg, or drop it entirely.
Are you taking the 700mg Magnesium for any particular reason ?
Maybe reduce Magnesium as well.

You really want to avoid excess calcium, because it can worsen Mag deficiency, among other problems.

Multi vit ( 1000mg calcium in it) please, be more specific. Don't forget calcium and vitamin D (but mostly high doses of calcium) could increase risk of kidney stones, in theory, such a high dose combination could even increase CVD risk, possibly via increased calcification. Consider vitamin K2 and slightly reducing vitamin D intake or cut out the calcium and regularly check blood levels.

My personal preference is for mk4, but mk7 should work fine.
I'd bump it up to about 100 mcg, though.

Edited by rwac, 22 April 2009 - 05:12 PM.

[rwac]

I thought 1000mg was an average dose; so I'm wondering what dose is recommended.

It's too much.
Are you taking it for bone health ?
If so, you might want to reduce it to 200-400 mg, and take D3+K2 as well.

If you don't have a particular reason to take it, perhaps drop it ?
Most people get a fair amount of calcium in food.

[kismet]

My personal preference is for mk4, but mk7 should work fine.
I'd bump it up to about 100 mcg, though.

Are you taking high doses of mk4? I'm not sure if low doses are effective at all (half life, etc), while the pharmacological doses (45mg; the dose drastically reducing osteoporotic fracture risk) may provide unique benefits over low dose MK-7 (and might be superior from that perspective), they could also have more unique (long-term) side-effects. 

EDIT: changed 'mcg' to 'mg'

Edited by kismet, 22 April 2009 - 11:39 PM.

[rwac]

Are you taking high doses of mk4? I'm not sure if low doses are effective at all (half life, etc), while the pharmacological doses (45mcg; the dose drastically reducing osteoporotic fracture risk) may provide unique benefits over low dose MK-7 (and might be superior from that perspective), they could also have more unique (long-term) side-effects.

I take 5 mg of mk4, but I used to take 10 mg.
I plan to switch over to the K2 drops at some point.
Perhaps 1mg ?

I'm thinking I used to be very deficient, I actually got some effects very similar to a niacin flush (but longer duration) from taking mk4.
This doesn't seem to be very common.

[JoL]

as for glucosamine , its glucosamine hcl . is that bad?

Yep, it's a waste of money. The only formulation that might work is the sulphate salt.

Why would the sulfate salt be working better than the chloride ?

[kismet]

I suppose different salts may be absorbed differently (one study in horses shows this to be the case(1)) or other mechanisms are involved. Does this make sense to you? I'm not so well versed in pharmacokinetics.
Some have also speculated that the sulphate is doing some good on its own. Maybe I'll look for human data tomorrow (need to update my glucosamine research anyway). Additionally (and obviously) the most recent human data on sulphate is better than on hydrochloride formulations and clinical data always trumps mechanistic speculation. However, I'm not impressed by the studies for any of the salts...

(1) Osteoarthritis Cartilage. 2008 Sep;16(9):973-9. Epub 2008 Mar 4.
Comparison of pharmacokinetics of glucosamine and synovial fluid levels following administration of glucosamine sulphate or glucosamine hydrochloride.
Meulyzer M, Vachon P, Beaudry F, Vinardell T, Richard H, Beauchamp G, Laverty S.

Edited by kismet, 22 April 2009 - 11:46 PM.