4 replies to this topic

[treonsverdery]

Hi there
This is research any imminster can try

bleach plus rubber cement thinner plus water creates new forms of resveratrol
here is a reference on chlorinating vitamin E with hypochlorous acid plus hexane http://www.ncbi.nlm....Pubmed_RVDocSum

chlorinating resveratrol such that a number of the hydrogens are replaced with chlorine atoms
maintaining high plasma levels of resveratrol is of benefit When a compound is halogenated the enzymes take longer to degrade the chemical
Further numerous chlorocompounds are dozens or hundreds of times more effective chlorosucrose known as splenda is 300 times as sweet as sugar Chloral hydrate is basically trichloroethanol It makes people sleepy at a dose of milligrams rather than grams

It is possible that chlororesveratrol is dozens or hundreds of times more potent as a longevity drug than resveratrol

I strongly suggest that imminsters with T-res try the bleach recipe then test the chlororesveratrol reaction products on yeast or other organisms
here is the recipe on making chlorotocopherol chlorovitamin e from the journal lipids

Reaction of γ-Tocopherol with Hypochlorous Acid
Quyen Nguyen1 and Peter T. Southwell-Keely

This is a study of the reactivity of γ-tocopherol with hypochlorous acid/hypochlorite Aqueous sodium hypochlorite (1.72 mmol; pH 7.4) was stirred with γ-tocopherol (0.12 mmol) in hexane for 2 min at room temperature. The following products were isolated: γ-tocopheryl quinone (0.6%), tocored (10%), 3-chloro-γ-tocopheryl quinone (14%), an ether dimer of 3-chloro-γ-tocopheryl quinone (0.4%), two isomers of 5-(5-γ-tocopheryl)-γ-tocopherol (3 and 2% respectively), 5-chloro-γ-tocopherol (14%) and two chlorinated dimers (14 and 24% respectively) which were identified as diastereomers of (3R,10R)-11a-chloro-2,3,9,10-tetrahydro-3,5,6,10,12,13-hexamethyl-3,10-bis[(4R,8R)-4,8,12-trimethyltridecyl]-1H-pyrano(3,2a)-8H-pyrano(3,2g)-dibenzofuran-14(7aH)(14aH)-one. The chlorinated dimers, 5-chloro-γ-tocopherol, 3-chloro-γ-tocopheryl quinone and its ether dimer are new compounds

typical reaction, 1 (50 mg, 0.12 mmol) was dissolved in hexane (3 mL) and stirred with NaOCl (128 mg, 1.72 mmol) in water (3 mL, adjusted to pH 7.4 with HCl) for 2 min at room temperature. The hexane layer was washed with water until neutral, dried (Na2SO4), and the solvent removed in vacuo. The residue was chromatographed on thin layers of silica gel using light petroleum/ethyl acetate (19:1, v/v) as eluting solvent


wikipedia says of bleach
Chemistry
The process of bleaching can be summarized in the following set of chemical reactions:

Cl2(aq) + H2O(l) H+(aq) + Cl-(aq) + HClO(aq)

The H+ ion of the hypochlorous acid then dissolves into solution, and so the final result is effectively:

Cl2(aq) + H2O(l) 2H+(aq) + Cl-(aq) + ClO-(aq)



T-res plus bleach plus rubber cement thinner 2 minutes at 30 C May be dozens to hundreds of times more effective at conferring longevity


There is a way to chlorinate organics described at http://www.shroomery...848740#10848740 as well

Edited by treonsverdery, 18 August 2009 - 01:28 AM.

[niner]

T-res plus bleach plus rubber cement thinner 2 minutes at 30 C May be dozens to hundreds of times more effective at conferring longevity

Or might kill you. There's no way to know a priori.

[treonsverdery]

T-res plus bleach plus rubber cement thinner 2 minutes at 30 C May be dozens to hundreds of times more effective at conferring longevity

Or might kill you. There's no way to know a priori.

It kind of depends on whether one is a yeast or other organism

actually this could be a plausible way to make money chlororesveratrol is new to bing thus a person willing to see what halogenated resveratrol does could get lots of sirtis shares if this obvious product is complementary to their process

all of my ideas at immint.org are public domain every person has the option to optimize the halogenation to become rich just visit the albertsons then measure the effects also a nifty way to bring imminst more visitors

[John Barleycorn]

There are two obvious reactions that phenols will undergo: halogenation and esterification. An example of the latter is acetylated resveratrol, which has already received a bit of press around here. It possibly could be done by refluxing resveratrol with glacial acetic acid and a water scavenging technique, but would be done more thoroughly with acetic anhydride. If someone doesn't know why the latter is tightly controlled then they've got some learning to do. A home synth isn't out of the question but starts to get legally complicated. The sulphuric ester is a possible alternative, but there are some traps there to do with the fact that sulphuric acid is also an oxidant.

And it occurs to me that isn't the sulphuric ester one of the objectionable conjugates of the liver anyway? I must admit that I've never quite got why esterification was regarded as such a problem in the first place. It is a standard means of making phenols and alcohols less polar and therefore more able to cross the blood-brain barrier, provided that the ester isn't hydrolysed in the gut.

Halogenation (which is really a type of oxidisation) could in theory be done with all sorts of agents, like hypochlorite, chlorine gas, bromine water, etc, plus something to maintain acidic conditions. However, whilst the reaction is theoretically kind of trivial, there are some practical gotchas. First, a solvent is needed for the resveratrol, and I don't think hexane is going to do it in the absence of a phase transfer catalyst. Something in the alcohol or ketone polarity range is probably required. Second, you don't want your solvent to oxidise in preference to the resveratrol. Third, there is the workup consideration, which is to say that you need to be able to separate your halo-resveratrol from the reactants and solvents. This might be kitchen chemistry, or it might not be ...

Apart from potency, one advantage of halo-resveratrol may be that it fools the liver and is orally active. One disadvantage, as already mentioned, is that toxicity has not been established. :(

[John Barleycorn]

And it occurs to me that isn't the sulphuric ester one of the objectionable conjugates of the liver anyway?

No, it's a sulphonate.