28 replies to this topic

[tlm884]

Today I started back to school and I have noticed that when someone asks me a question that I know the answer too I just can't get the answer out. It is on the tip of my tounge and as soon as I find the answer out I am like duh I knew that.

I am currently on

Escitalopram 5mg
Propranolol 80mg
Diovan 80mg

and 2 tablets of Ortho-mind a day.

Can any of this be causing this or is it most likely something else?

[Lufega]

I've been using methylene blue and it has helped tremendously in this area. Check the threads here.

[Declmem]

I've got this problem, to an extent. The tip-of-the-tongue is more or less a persistent phenomenon in my life, and getting rid of it is the most important goal in my experimentations.

I'm also taking Escitalopram, but the memory problems occurred long before then. Amusingly, I was prescribed Escitalopram by my doctor after telling him about the memory problems I'm having! Sorry, can't help you with memory problems, but I can cheer you up.

It didn't help for memory, but serendipitously helped with social anxiety and other problems, so I stuck with it.

I've been using methylene blue and it has helped tremendously in this area. Check the threads here.

Hi Lufega, I'm really hoping to try this. I may have asked you this before, but can you let me know two important things:

1) Where exactly do you get your MB from?

2) How to dose it, specifically? (a dropper in X ml of water, or what?)

(sorry to hijack the thread for MB)

Edited by Declmem, 03 September 2009 - 06:08 PM.

[tlm884]

I've got this problem, to an extent. The tip-of-the-tongue is more or less a persistent phenomenon in my life, and getting rid of it is the most important goal in my experimentations.

I'm also taking Escitalopram, but the memory problems occurred long before then. Amusingly, I was prescribed Escitalopram by my doctor after telling him about the memory problems I'm having! Sorry, can't help you with memory problems, but I can cheer you up.

It didn't help for memory, but serendipitously helped with social anxiety and other problems, so I stuck with it.

I've been using methylene blue and it has helped tremendously in this area. Check the threads here.

Hi Lufega, I'm really hoping to try this. I may have asked you this before, but can you let me know two important things:

1) Where exactly do you get your MB from?

2) How to dose it, specifically? (a dropper in X ml of water, or what?)

(sorry to hijack the thread for MB)

I have looked into MB before but I did not know if the MAOI properties of the MB would interact with Escitalpram. Also, would it be okay to take MB meant for fish tanks?

[niner]

Today I started back to school and I have noticed that when someone asks me a question that I know the answer too I just can't get the answer out. It is on the tip of my tounge and as soon as I find the answer out I am like duh I knew that.

I am currently on

Escitalopram 5mg
Propranolol 80mg
Diovan 80mg

and 2 tablets of Ortho-mind a day.

Can any of this be causing this or is it most likely something else?

The excitalopram could be it. 5 mg's not a huge dose though. Other people report memory problems from lexapro, if you google lexapro and memory, you'll see it. It's also been shown to improve memory in people with major depressive disorder. Do you find that you need the propranolol on top of the Diovan? I don't think the propranolol would have much effect on memory, unless maybe you aren't getting enough blood to your brain, but I'd think you'd feel that.

[tlm884]

Today I started back to school and I have noticed that when someone asks me a question that I know the answer too I just can't get the answer out. It is on the tip of my tounge and as soon as I find the answer out I am like duh I knew that.

I am currently on

Escitalopram 5mg
Propranolol 80mg
Diovan 80mg

and 2 tablets of Ortho-mind a day.

Can any of this be causing this or is it most likely something else?

The excitalopram could be it. 5 mg's not a huge dose though. Other people report memory problems from lexapro, if you google lexapro and memory, you'll see it. It's also been shown to improve memory in people with major depressive disorder. Do you find that you need the propranolol on top of the Diovan? I don't think the propranolol would have much effect on memory, unless maybe you aren't getting enough blood to your brain, but I'd think you'd feel that.

The diovan is for hypertension and the propranolol is for anxiety. I doubt its lack of blood flow to the brain as Ortho-mind has both Ginkgo and Vinpocetine in it.

I believe I also have a choline deficiney due to having "stimulant blues". So I ordered a bottle of Citicoline yesterday, Sublingual P5P, Theanine, and Rhodiola Rosea.

[Declmem]

Citicoline is extremely helpful. It didn't cure my problem 100%, but really, really helps.

[rwac]

I have looked into MB before but I did not know if the MAOI properties of the MB would interact with Escitalpram. Also, would it be okay to take MB meant for fish tanks?

It really shouldn't behave as a MAOI at the 60 mcg dose we're using.

Tropical fish are very sensitive to heavy metals and other toxic stuff, plus we're diluting it down a fair bit.

Also, Just so you know, you won't feel it as much if you're supplementing CoQ10.

[Declmem]

I have looked into MB before but I did not know if the MAOI properties of the MB would interact with Escitalpram. Also, would it be okay to take MB meant for fish tanks?

It really shouldn't behave as a MAOI at the 60 mcg dose we're using.

Tropical fish are very sensitive to heavy metals and other toxic stuff, plus we're diluting it down a fair bit.

Also, Just so you know, you won't feel it as much if you're supplementing CoQ10.

Can you give a bit more specific information? Such as where you are purchasing it from, and exactly how you're diluting it?

Would really appreciate it since I've been wanting to try this for a while.

[rwac]

Can you give a bit more specific information? Such as where you are purchasing it from, and exactly how you're diluting it?

Would really appreciate it since I've been wanting to try this for a while.

I use kordon 2.303% solution MB. I bought it from a nearby aquarium store.


Dosage:

I take 32 drops of 2% solution (1.6 full eyedropers)which equals 36.8 mg MB added to 30 ml water. Each drop of this should equal 60 micrograms per drop.

 methylene_blue.jpg   12.72KB   29 downloads

[amere]

I am currently on

Escitalopram 5mg
Propranolol 80mg
Diovan 80mg

People seem to be leaning toward escitalopram but it's a fairly low dose and you say the problem's pre-existing. I'd lean toward the propranolol. When I tried it, I remember being overcome by apathy to the point that I couldn't be bothered to search my mind for things that didn't come to me instantly. There was blunting of my memory beyond that aswell but it's hard to discern at this distance in time. Just my experience.

As for solutions, I'll second the choline and maybe suggest creatine and rosemary. Lithium orotate has some great research behind it too if you want to look into that aswell.

[niner]

I am currently on

Escitalopram 5mg
Propranolol 80mg
Diovan 80mg

People seem to be leaning toward escitalopram but it's a fairly low dose and you say the problem's pre-existing. I'd lean toward the propranolol. When I tried it, I remember being overcome by apathy to the point that I couldn't be bothered to search my mind for things that didn't come to me instantly. There was blunting of my memory beyond that aswell but it's hard to discern at this distance in time. Just my experience.

As for solutions, I'll second the choline and maybe suggest creatine and rosemary. Lithium orotate has some great research behind it too if you want to look into that aswell.

You know, that's an interesting observation regarding propranolol. The OP could pretty easilly stop propranolol for a while and see if that's it. I'm less inclined to experimentally stop an SSRI, but if the need for it is not great, it would be a thing to consider dropping.

[Declmem]

I bought some propranolol but haven't tried it yet. Have you heard of the study using propranolol for PTSD? Essentially, if you recall a memory while on propranolol, it can take the emotional "bite" out of the memory, permanently.

So, there is no doubt that propranolol can permanently affect memory.

Also musicians often use propranolol for stage fright.

These are the two reasons I purchased it for. I wouldn't personally use it on a daily basis.

tlm884, is there a different beta blocker you could use?

[tlm884]

I bought some propranolol but haven't tried it yet. Have you heard of the study using propranolol for PTSD? Essentially, if you recall a memory while on propranolol, it can take the emotional "bite" out of the memory, permanently.

So, there is no doubt that propranolol can permanently affect memory.

Also musicians often use propranolol for stage fright.

These are the two reasons I purchased it for. I wouldn't personally use it on a daily basis.

tlm884, is there a different beta blocker you could use?

The thing with the propranolol is that it works INCREDIBLY well for my anxiety. I have done a little research on other beta blockers but they all seem to be associated with memory loss to the extent of propranolol I am not sure. I am reluctant to stop because it has worked so well. Aswell, since I am using it to reduce epinephrine in the perphiry I need a non-selective beta blocker that affects the brain and heart not a selective one that affects only the heart.

Does anyone have any other suggestions on how to reduce stress (pharmacologically speaking) that does not impair memory. SSRI's do not really work because I have bipolar depression and they seem to worsen it without the use of a mood stabalizer and I can't tolerate mood stabalizers. However, I did not try low dose lithium.

I am going to talk to my shrink next week and get an RX for modafinil.

[tlm884]

I bought some propranolol but haven't tried it yet. Have you heard of the study using propranolol for PTSD? Essentially, if you recall a memory while on propranolol, it can take the emotional "bite" out of the memory, permanently.

So, there is no doubt that propranolol can permanently affect memory.

Also musicians often use propranolol for stage fright.

These are the two reasons I purchased it for. I wouldn't personally use it on a daily basis.

tlm884, is there a different beta blocker you could use?

The thing with the propranolol is that it works INCREDIBLY well for my anxiety. I have done a little research on other beta blockers but they all seem to be associated with memory loss to the extent of propranolol I am not sure. I am reluctant to stop because it has worked so well. Aswell, since I am using it to reduce epinephrine in the perphiry I need a non-selective beta blocker that affects the brain and heart not a selective one that affects only the heart.

Does anyone have any other suggestions on how to reduce stress (pharmacologically speaking) that does not impair memory. SSRI's do not really work because I have bipolar depression and they seem to worsen it without the use of a mood stabalizer and I can't tolerate mood stabalizers. However, I did not try low dose lithium.

I am going to talk to my shrink next week and get an RX for modafinil.

Does anyone know if the memory loss of pindolol is less then that of propranolol.

[tlm884]

As well, does anyone know if OrthoMind can cause over stimulation?

[tunt01]

Can you give a bit more specific information? Such as where you are purchasing it from, and exactly how you're diluting it?

Would really appreciate it since I've been wanting to try this for a while.

I use kordon 2.303% solution MB. I bought it from a nearby aquarium store.


Dosage:

I take 32 drops of 2% solution (1.6 full eyedropers)which equals 36.8 mg MB added to 30 ml water. Each drop of this should equal 60 micrograms per drop.

 methylene_blue.jpg   12.72KB   29 downloads

i actually bought this exact bottle a few weeks ago and have it sitting on my shelf. just been sidetracked on other things.

how to you use it? do you take all 30 ml at once? don't you space it throughout the day? i thought i read previously that it was 3 separate doses of 60mcg throughout the day.

[Lufega]

Prophet,

Each drop of the 30 ml solution will have 60 mcg. Dose this 3x a day. I get away with twice daily and sometimes just one.

[tlm884]

Today I started 50mg of Modafinil for 5 days and increase to 100mg for 10 days. After that I am suppose to see the shrink again to see if its helping.

[Declmem]

Cool, let us know how it works out.

I've been trying Methylene Blue this week. It isn't doing anything overtly obvious. Perhaps a slight effect. It is early though. I'll keep with it for a while yet.

[rwac]

I've been trying Methylene Blue this week. It isn't doing anything overtly obvious. Perhaps a slight effect.

Declmem, do you have a link to the rest of your regimen ?
Also, what's the dose you're using ? Did you try half or quarter the dose ?

[Declmem]

I've been trying Methylene Blue this week. It isn't doing anything overtly obvious. Perhaps a slight effect.

Declmem, do you have a link to the rest of your regimen ?
Also, what's the dose you're using ? Did you try half or quarter the dose ?

I'm also using:

Pantothenic Acid
CDP Choline
Salmon Oil
D3
Iodine
Lexapro

Every other day I use doxylamine to help me sleep.

I was also using Guggul until yesterday when I stopped for unrelated reasons.

Also, just today I experimented with adding NAD to the mix.

Regarding MB, what I did:

Since the dropper bottle I bought wouldn't hold 30ml I couldn't use the plan outlined, so I did something similar, I added half a ml of MB to 7.5 ml of water, and used a drop of that 3x a day for the first few days. Then I upped that to 2 drops. And today I tried 3. Three may have potential - I had a good memory and good verbal fluency this evening. But that could also be the NAD. Too early to tell.

In case it matters, I drop into a cup of water, swirl it around, and then drink that. Otherwise it turns my tongue blue.

I know there is speculation that diluting the MB even to 1mcg may actually make it more effective. I haven't tried that yet. I'm not dismissing it (though it does seem a bit homeopathic for my taste). I may try diluting it further later on.

Any comments?

[rwac]

I know there is speculation that diluting the MB even to 1mcg may actually make it more effective. I haven't tried that yet. I'm not dismissing it (though it does seem a bit homeopathic for my taste). I may try diluting it further later on.

Any comments?

I kinda have the feeling that somehow supplemental CoQ10 interferes with MB, and that's why 1mcg was effective for me originally.

Anyway, it's not very effective if you take too little or too much.
Sounds like you might still benefit from bumping it up...

[tlm884]

I know there is speculation that diluting the MB even to 1mcg may actually make it more effective. I haven't tried that yet. I'm not dismissing it (though it does seem a bit homeopathic for my taste). I may try diluting it further later on.

Any comments?

I kinda have the feeling that somehow supplemental CoQ10 interferes with MB, and that's why 1mcg was effective for me originally.

Anyway, it's not very effective if you take too little or too much.
Sounds like you might still benefit from bumping it up...

Hm. CoQ10 and MB both work in the mitochondria and I would hypothesize that they might complement eachother?

[rwac]

Hm. CoQ10 and MB both work in the mitochondria and I would hypothesize that they might complement eachother?

You would think so, but it doesn't seem to work that way.
My theory is that MB replaces CoQ10 to generate the Nootropic effect, and somehow adding CoQ10 interferes with this process ...

[tlm884]

I started modafinil and well so far I don't think its all that great. At 50mg I was doing good, more energy no affect on attention alothugh. At 100mg I noticed extreme fatigue without the ability to go to sleep and no change in attention.

[Declmem]

I started modafinil and well so far I don't think its all that great. At 50mg I was doing good, more energy no affect on attention alothugh. At 100mg I noticed extreme fatigue without the ability to go to sleep and no change in attention.

It never helped with my memory problems, personally.

[tunt01]

i dont want to hijack the thread, but anyone know what the LT risks of MB supplementation are?

[rwac]

i dont want to hijack the thread, but anyone know what the LT risks of MB supplementation are?

Here's a clinical study that tested the safety of MB at much higher doses (16 or 200 mg) for bipolar over 6 months.
http://clinicaltrial...how/NCT00214877

Unfortunately it doesn't mention the results...