9 replies to this topic

[DaffyDuck]

I won't mention the product directly by name that I have but it's one of the popular brands here. 99% resv from japanese knotweed.

It took me a while to narrow down what was causing the symptoms because I was almost certain I was developing allergies to fish oil at first.

The symptoms are reddish/purplish patches on my face. One on my forehead and one on my check. The location is always consistent. They are not raised. They itch slightly but the itch is not worsened by scratching. The other symptom is a slightly dizzy feeling. Since I have gone off Resveratrol for several weeks, the patches have faded but are still somewhat visible. No longer reddish or purplish, just a little darker. There are currently no symptoms.

I'm assuming I'm having an allergic reaction to some component of the plant. Are there any other good sources of Resveratrol?

[niner]

You could try one of the high purity resveratrols that comes from cell culture instead of the plant. That should be free of any of the other compounds from the plant, though it might have some new ones of its own. You might be having a reaction to the resveratrol itself, in which case you are stuck. Wait for one of the high-dollar pharmaceuticals from Sirtris/GSK? Or maybe it's not the resveratrol at all, and the timing was just a coincidence.

[2tender]

If your product was pure and non-compunded, chances are any type will produce the same effects. This happens with all supplements for certain individuals, all most everyone has a supplement they cant take, if you're taking multiple supplements you use the process of elimination to determine which one is causing the unwanted effect. Its important to avoid anything that gives you a physical reaction. JMO

[opendoor]

Reactions are interesting. I had a reaction when I went to 500mg, but could be coincidence, and never had that again. A friend had the same reaction with just 100mg, also went away in a few hours, and he kept taking. Another friend said 100mg made him dizzy so stopped. Others at just 100mg say they feel nothing good or bad.

I wonder if even the Glaxo pills will only benefit 80%-90% of the population until they learn how to tweak further.

[maxwatt]

This is the second report I have seen of a rash associated with (high-purity) resveratrol use.

The first instance whas variously diagoned as eczema, contact dermatitis, allergies and seemed to be set off by many different things including tomato plants, though it was first noticed with resveratrol in powdered form. Pregnenolone from one batch would also set off the rash, whilst pregnenolone from a different source did not. At this point I am told it is being treated as celiac disease, a sensitivity to gluten. On a gluten free diet, the condition is subsiding. With time she hopes to resume use of resveratrol.

I wonder what is used as an excipient? Corn starch sometimes is, perhaps some gluten contamination is occuring with some supplements?

[2tender]

Excipients, binders, food coloring of capsules, change in manufacturer of one of the ingredients, diet, Medications, all these and more can contribute to a reaction. In my opinion its always best to stop all supplements and then add them over a period of time to see what is the cause. The purpose of supplementing is to enhance wellness and health, using the best available is always prudent.

[DaffyDuck]

Excipients, binders, food coloring of capsules, change in manufacturer of one of the ingredients, diet, Medications, all these and more can contribute to a reaction. In my opinion its always best to stop all supplements and then add them over a period of time to see what is the cause. The purpose of supplementing is to enhance wellness and health, using the best available is always prudent.

I don't take many supplements. Currently just fish oil and black raspberry powder (if that could be considered a supplement) so it didn't take to long to narrow down the cause.

[DaffyDuck]

This is the second report I have seen of a rash associated with (high-purity) resveratrol use.

The first instance whas variously diagoned as eczema, contact dermatitis, allergies and seemed to be set off by many different things including tomato plants, though it was first noticed with resveratrol in powdered form. Pregnenolone from one batch would also set off the rash, whilst pregnenolone from a different source did not. At this point I am told it is being treated as celiac disease, a sensitivity to gluten. On a gluten free diet, the condition is subsiding. With time she hopes to resume use of resveratrol.

I wonder what is used as an excipient? Corn starch sometimes is, perhaps some gluten contamination is occuring with some supplements?

Thanks. I'll keep this in mind and see if I have an issue with gluten. The most bizarre part is that the spots appear in the same exact locations.

[DaffyDuck]

Reactions are interesting. I had a reaction when I went to 500mg, but could be coincidence, and never had that again. A friend had the same reaction with just 100mg, also went away in a few hours, and he kept taking. Another friend said 100mg made him dizzy so stopped. Others at just 100mg say they feel nothing good or bad.

I wonder if even the Glaxo pills will only benefit 80%-90% of the population until they learn how to tweak further.

I haven't tried different doses, however I did notice the rashes got a redder and itchier when I swished the powder in my mouth for a while with some grape juice. I haven't tried it again just to be sure it wasn't coincidence so I might do that.

Edit: To clarify, at it's worst, the itchiness is relatively mild. Nothing like poison ivy itch.

Edited by DaffyDuck, 02 October 2009 - 12:19 AM.

[2tender]

Now that I think about it, the rash you described sounds exactly the same as reports from people that used a transdermal supplement with Resveratrol in it. There could be a correlation, some people may break out from it. People often get the same reaction from fruit juices and grape extracts.