first of all: how old are you?
if you're under 50, you don't stand to gain much from the acetylcholinesterase inhibitors that you can't gain much more safely with some of the cholinergic precursors.
second of all, if you ARE going to use the AChEIs, don't waste your money on galantamine. if you don't plan on taking galantamine chronically, the dopamine agonist effect it has will probably never be comfortable. from personal experience, galantamine is okay, but way overpriced. huperzine is pretty decent, and i like the NMDA-receptor antagonist effect that it has. that said, it's completely unnecessary for young people, because our bodies are pretty darn good at converting choline to acetylcholine. supplemental choline is cheaper, safer, and depending on what form of choline you're using, offers more to gain from chronic use.
and as Irish MD said, combining choline with AChEIs is dangerous.
I'm 20 years old and am not currently taking choline. I have found that CDP-Choline and Alpha-GPC do almost nothing for me and have intolerable side effects, whereas Choline Bitartrate, while tolerable has some benefit but far less so than Huperzine A. I haven't the slightest clue why Huperzine A makes such a profound difference - more so than virtually every other supplement I have tried recently. If what you say is true, and my brain should have plenty of acetylcholine, than either my brain isn't functional in that regard or it simply functions better with more acetylcholine. It is possible that I am benefiting from Huperzine A's NMDA antagonism as opposed to its inhibition of acetylcholinesterase? I simply haven't noticed anything even approaching the cognitive clarity of Huperzine A from choline sources or piracetam, aniracetam, or oxiracetam which are cholinergics.
Edited by qwerty3, 04 November 2009 - 10:49 AM.