[zawy]

This is to collect and summarize anecdotal resveratrol reports. I'll try to modify this top post as people post their experience in this thread. Please make posts as brief as possible and follow the format below. Please look for your name in the list below and post to make a change. A change in dosage means a new entry. A relatively close variation in dosing should be averaged to one number. Please delete this list from your message when posting a reply.

People reporting: 29

Benefits:
improved energy/endurance: 13
improved mood: 10
decreased appetite/weight loss: 5
improved hair growth: 5 maybe's
decreased OsteoArthritis (OA): 3
decreased coffee: 2
decreased non-OA pains: 1
require less sleep: 1
increased sex drive: 1

Problems:
increased tendinitis: 6
increased non arthritis, non tendinitis pains: 2
increased obsessive: 2
increased RA arthritis: 1
increased aggression: 1
increased jittery: 2 at beginning (supposedly only on 50%)
laxative: 2 at beginning (supposedly only on 50%)

Please Post in this Format:
name, RESV in g/day, purity, summary of effects

alterego, 0.2,, no RA problems, better mood
alterego, 1.2, 99%, exacerbated rheumatoid arthritis, best mood
anthony_loera,2,99%,improved mood,attitude,well being, recovery, normal (revgenetics supplier)
bixbyte,1,,more hair and nail growth
drmz, 0.6,, knees and ankles
edward, 1,, tennis elbow (increased tennis playing)
edward, 2.3,, no tennis=no tenniselbow
enzyme, 0.6,, hamstring tendinitis
eternalone, 0.3,, improved energy, loss of desire for alcohol, appetite suppressant
fearfrost, 0.5,, quercetin definite energy boost
full_membr, 2,,"crawling out of my skin" with paxil for a day or two when upping the dose from 1 g/d. settled back to 1.5
health_nutty, 0.4,, improved mood and energy, definite appetite suppressant
kenj, 1.1, 99%, achilles tendinitis (run 30-40 mins)
makoss, 0.5,, jolt of energy, appetite suppressant
markymark, 0.225,25%, more energy
matt, ,, ankle tendinitis
maxwatt, 3,, well being and increased energy that returns to baseline after awhile, fewer colds, less arthritis
missminni, 1.75,98%,no more lower back pain from sitting, better knees, cured morton's nueroma, better mood, more agile
missminni_dad,,,improved OA
proteomist, 0.5, 50%, stimulant and laxative effects that subsided
quarter, 0.5, 50%, achilles tendinitis (high impact sprint training)
rhc124, 1.2, 50%, hip pain (worked wonders for my depression and anxiety)
scorpe, 0.8,, fewer colds, less knee pain, increased sex drive
shadowrun, 0.2,, in morning imrpoved energy and alertness, slight headache...will not take at night
stephe_b,2,,back pain, between shoulder blades
tayo,2,,nothing reported, weight lifter experimenting with 5g/d
tintinet, 5, 99%, tennis elbow, hair, "due to playing guitar obsessively" "persistent buoyant mood and general sense of robust physical and mental wellness", decreased appetite, less sleep needed
velopismo, 2.25,98%,increased endurance and power output (road cycling as measured by a powertap), general feeling of well being, aggression, reduced body weight set-point 4%, possible knee pain from applying DMSO/Resv to knee (but could have been by over stressing knee during a sprint).
velopismo_wife,1,98%,very apparent increased energy, weight loss
xanadu, 0.07, 50%, improved energy and mood
zawy, 0.9,, improved energy, hair, loss of desire for coffee, increased obsessive, less arthritis, possible male-pattern baldness improvement after 6 months at 0.2 g/d

Caveats: The laxative effect reported by a few may be due to the emodin in 50% formulations. Tendinitis and arthritis may result from an incresae in activity from an increase in mood/energy/aggression.

This post has been edited by zawy: 15 January 2008 - 04:09 AM

[health_nutty]

Nice summary. Thanks for doing the legwork.

[maxwatt]

The one negative arthritis effect is for rheumatoid arthritis, not osteoarthritis. Resveratrol can negatively impact some autoimmune diseases, as activating Sirt1 exacerbates them. Distinguish between the two forms of arthritis.

Diarrhea is inevitable with large dose from 50% extract, due to the inevitable emodin content. However, even pure resveratrol can cause diahrrea b causing the intestinal caco cells to excrete chloride. This can be controlled by certain herbs, or by the use of butyrate which is available as calcium butyrate, or as a prescription medication. HMB may also contain enough butyrate o prevent said diahrrhea.

zawy, on 14-Jan 2008, 12:43 PM, said:

This is to collect and summarize anecdotal resveratrol reports. I'll try to modify this top post as people post their experience in this thread. Please make posts as brief as possible and follow the format below. Please look for your name in the list below and post to make a change. A change in dosage means a new entry. A relatively close variation in dosing should be averaged to one number.

Benefits:
improved energy: 11
improved mood: 7
decreased appetite: 3
decreased arthritis: 2
decreased coffee: 2
increased sex drive: 1

Problems:
increased tendinitis: 6
increased other joint pains: 2
increased arthritis: 1
increased obsessive: 2
increased aggression:

Please Post in this Format:
name, RESV in g/day, purity, summary of effects

rhc124, 1.2, 50%, hip pain (worked wonders for my depression and anxiety)
quarter, 0.5, 50%, achilles tendinitis (high impact sprint training)
kenj, 1.1, 99%, achilles tendinitis (run 30-40 mins)
alterego, 1.2, 99%, exacerbated rheumatoid arthritis, best mood
alterego, 0.2,, no RA problems, better mood
matt, ,, ankle tendinitis
drmz, 0.6,, knees and ankles
enzyme, 0.6,, hamstring tendinitis
tintinet, 5, 99%, tennis elbow, "Seems to be due to playing guitar obsessively" " persistent buoyant mood and general sense of robust physical and mental wellness"
edward, 1,, tennis elbow (increased tennis playing)
edward, 2.3,, no tennis=no tenniselbow
maxwatt, 3,, well being and increased energy that returns to baseline after awhile, fewer colds, less arthritis
health_nutty, 0.4,, improved mood and energy, definite appetite suppressant
makoss, 0.5,, jolt of energy, appetite suppressant
eternalone, 0.3,, improved energy, loss of desire for alcohol, appetite suppressant
zawy, 0.9,, improved energy, loss of desire for coffee, increased obsessive, less arthritis, possible male-pattern baldness improvement after 6 months at 0.2 g/d
fearfrost, 0.5,, quercetin definite energy boost
shadowrun, 0.2,, in morning imrpoved energy and alertness, slight headache...will not take at night
scorpe, 0.8,, fewer colds, less knee pain, increased sex drive
markymark, 0.225,25%, more energy
proteomist, 0.5, 50%, stimulant and laxative effects that subsided
xanadu, 0.07, 50%, improved energy and mood

Caveats: The laxative effect reported by a few may be due to the emodin in 50% formulations. Tendinitis and arthritis may result from an incresae in activity from an increase in mood/energy/aggression.

[tintinet]

Just a minor addition: I also seem to have generally decreased appetite and appear to require (although I'd like the luxury of more) little sleep.

[missminni]

zawy, on 14-Jan 2008, 12:43 PM, said:

This is to collect and summarize anecdotal resveratrol reports. I'll try to modify this top post as people post their experience in this thread. Please make posts as brief as possible and follow the format below. Please look for your name in the list below and post to make a change. A change in dosage means a new entry. A relatively close variation in dosing should be averaged to one number.

People reporting: 27

Benefits:
improved energy: 11
improved mood: 8
improved hair growth: 5 maybe's
decreased appetite: 3
decreased arthritis: 2
decreased coffee: 2
increased sex drive: 1

Problems:
increased tendinitis: 6
increased other joint pains: 2
increased RA arthritis: 1
increased obsessive: 2
increased aggression: 1
increased jittery: 2 at beginning (supposedly only on 50%)
laxative: 2 at beginning (supposedly only on 50%)

Please Post in this Format:
name, RESV in g/day, purity, summary of effects

rhc124, 1.2, 50%, hip pain (worked wonders for my depression and anxiety)
quarter, 0.5, 50%, achilles tendinitis (high impact sprint training)
kenj, 1.1, 99%, achilles tendinitis (run 30-40 mins)
alterego, 1.2, 99%, exacerbated rheumatoid arthritis, best mood
alterego, 0.2,, no RA problems, better mood
matt, ,, ankle tendinitis
drmz, 0.6,, knees and ankles
enzyme, 0.6,, hamstring tendinitis
tintinet, 5, 99%, tennis elbow, hair, "Seems to be due to playing guitar obsessively" " persistent buoyant mood and general sense of robust physical and mental wellness"
edward, 1,, tennis elbow (increased tennis playing)
edward, 2.3,, no tennis=no tenniselbow
maxwatt, 3,, well being and increased energy that returns to baseline after awhile, fewer colds, less arthritis
health_nutty, 0.4,, improved mood and energy, definite appetite suppressant
makoss, 0.5,, jolt of energy, appetite suppressant
eternalone, 0.3,, improved energy, loss of desire for alcohol, appetite suppressant
zawy, 0.9,, improved energy, hair, loss of desire for coffee, increased obsessive, less arthritis, possible male-pattern baldness improvement after 6 months at 0.2 g/d
fearfrost, 0.5,, quercetin definite energy boost
shadowrun, 0.2,, in morning imrpoved energy and alertness, slight headache...will not take at night
scorpe, 0.8,, fewer colds, less knee pain, increased sex drive
markymark, 0.225,25%, more energy
proteomist, 0.5, 50%, stimulant and laxative effects that subsided
xanadu, 0.07, 50%, improved energy and mood
bixbyte,1,,more hair and nail growth
full_membr, 2,,"crawling out of my skin" with paxil for a day or two when upping the dose from 1 g/d. settled back to 1.5
missminni, 1.5,,nothing reported
velopismo, 2,,increased aggression
stephe_b,2,,back pain, between shoulder blades
tayo,2,,nothing reported, weight lifter experimenting with 5g/d
anthony_loera,2,99%,improved mood,attitude,well being, recovery, normal (revgenetics supplier)

Caveats: The laxative effect reported by a few may be due to the emodin in 50% formulations. Tendinitis and arthritis may result from an incresae in activity from an increase in mood/energy/aggression.

I am taking 1.5 to 2 grams a day combining orally and transdermally.
I take 98.7% pure white powder. When I take orally, I dissolve it in my mouth with milk.
I mentioned these benefits, but on a different thread.
They are:
no more lower back pain after sitting for extended periods of time. I used to not be able to sit for more than 30 minutes without
having a severe back ache and not being able to straighten up right away. Now, I have no problem after sitting for hours.
Mortons Nueroma 95% gone. I used to be able to only walk a few blocks before pain would become untenable.
Now, I can walk for miles before feeling any discomfort at all, if at all.
knees don't hurt when rising from squat. They used to creak and hurt when i would rise from a squatting position.
stretching is easier. body more agile, less stiffness all around.
feeling of well being.
when mixed with DMSO and rubbed on ache or stiff neck, it relieves it within minutes.
also add to that my Dad, 92 with osteo arthritis has gotten tremendous relief from Res...98.7% pure powder...his back and legs.
It has enabled him to go relatively pain free and increased the distance he can walk and his stretching ability.
~ETA~friend who is a dancer takes about 1 gram day (she is 100 lbs) and it has dramatically reduced her joint pains,
of which there were many, considering she had a back injury and surgery that gave her chronic pain for years.
She also experienced increased agility and stretching is easier too.


.

This post has been edited by missminni: 15 January 2008 - 03:44 AM

[velopismo]

Velopismo/ 2-2.5g a day/ 98% / Increased endurance and power output (road cycling as measured by a powertap), general feeling of well being, aggression, reduced body weight set-point 4%.
The bad: possible knee pain from applying DMSO/Resv to knee (but could have been by over stressing knee during a sprint).

Velopismo's Wife/ 1g a day / 98% / Increased energy (very apparent, some people at her jobs are asking "what are you taking?") Increased energy lets her work two jobs (nursing) which increased our wealth. Weight loss. She has always been very sensitive to drugs. The bad: None reported.

[inawe]

Unless I missed it, nobody reported lower blood glucose when taking RSV. This is very curious given that the best known clinical trial (the only one?) of RSV in humans is for the treatment of diabetes. The effect on blood glucose is much less dependent on placebo than other things that have been reported.
Guarente et al. studied Sirt1 KO mice and found that they produce less insulin. But, in PMID: 16366736 they state:"Levels of blood glucose were then determined and,
surprisingly, were lower in Sirt1 KO mice (Figure 2D).
Further, these mice appeared to be hypermetabolic, since
they ate more food per body weight than the wild-type
(unpublished data). These findings suggested that the KO
mice had a better ability to use the lower levels of insulin for
glucose uptake, i.e., were more insulin sensitive."
WOW! Lower or no Sirt1 leads to less insulin and lower blood glucose. Cannot get much better than that. If the opposite holds true, by up-regulating Sirt1 we are increasing both the insulin and blood glucose circulating in our system.
Further, "Sirt1 represses the uncoupling protein (UCP) gene UCP2". But "UCPs may confer benefit by damping production
of reactive oxygen species during respiration. In one
example, mitochondria from UCP3 KO mice generated
higher levels of superoxide [53,54], suggesting that some
degree of uncoupling can be beneficial by controlling reactive
oxygen species production [55]."
Somebody has to ask Guarente if he takes RSV.

[zawy]

I would cut back if i thought resv was raising my blood suger. That's deadly.

[maxwatt]

zawy, on 16-Jan 2008, 06:04 PM, said:

I would cut back if i thought resv was raising my blood suger. That's deadly.

Resveratrol does not lower fasting glucose, but it increases insulin sensitivity. Other things lower blood glucose. That's why Sirtris is testing SRT501 in conjunction with metformin for diabetes.

[inawe]

maxwatt, on 16-Jan 2008, 08:35 PM, said:

zawy, on 16-Jan 2008, 06:04 PM, said:

I would cut back if i thought resv was raising my blood suger. That's deadly.

Resveratrol does not lower fasting glucose, but it increases insulin sensitivity. Other things lower blood glucose. That's why Sirtris is testing SRT501 in conjunction with metformin for diabetes.

Well. Guarente has a much different view: "These findings suggested that the (Sirt1) KO
mice had a better ability to use the lower levels of insulin for
glucose uptake, i.e., were more insulin sensitive."(PMID: 16366736). That paper is as clear as can be. I interpret this as meaning that down-regulating Sirt1 leads to less insulin production but lower blood glucose. That is, much better insulin sensitivity. The wild mice with more Sirt1 had much worse insulin sensitivity.
I take RSV so I'm worried by that paper, which by the way is free.

[maxwatt]

inawe, on 17-Jan 2008, 11:55 AM, said:

maxwatt, on 16-Jan 2008, 08:35 PM, said:

zawy, on 16-Jan 2008, 06:04 PM, said:

I would cut back if i thought resv was raising my blood suger. That's deadly.

Resveratrol does not lower fasting glucose, but it increases insulin sensitivity. Other things lower blood glucose. That's why Sirtris is testing SRT501 in conjunction with metformin for diabetes.

Well. Guarente has a much different view: "These findings suggested that the (Sirt1) KO
mice had a better ability to use the lower levels of insulin for
glucose uptake, i.e., were more insulin sensitive."(PMID: 16366736). That paper is as clear as can be. I interpret this as meaning that down-regulating Sirt1 leads to less insulin production but lower blood glucose. That is, much better insulin sensitivity. The wild mice with more Sirt1 had much worse insulin sensitivity.
I take RSV so I'm worried by that paper, which by the way is free.

'Then why is Guarante no working for Sirtris, and why are they testing SRT501 formulated resveratrol to improve insulin sensitivity?

[inawe]

maxwatt, on 17-Jan 2008, 01:20 PM, said:

inawe, on 17-Jan 2008, 11:55 AM, said:

maxwatt, on 16-Jan 2008, 08:35 PM, said:

zawy, on 16-Jan 2008, 06:04 PM, said:

I would cut back if i thought resv was raising my blood suger. That's deadly.

Resveratrol does not lower fasting glucose, but it increases insulin sensitivity. Other things lower blood glucose. That's why Sirtris is testing SRT501 in conjunction with metformin for diabetes.

Well. Guarente has a much different view: "These findings suggested that the (Sirt1) KO
mice had a better ability to use the lower levels of insulin for
glucose uptake, i.e., were more insulin sensitive."(PMID: 16366736). That paper is as clear as can be. I interpret this as meaning that down-regulating Sirt1 leads to less insulin production but lower blood glucose. That is, much better insulin sensitivity. The wild mice with more Sirt1 had much worse insulin sensitivity.
I take RSV so I'm worried by that paper, which by the way is free.

'Then why is Guarante no working for Sirtris, and why are they testing SRT501 formulated resveratrol to improve insulin sensitivity?

Very good questions. Another good question is how come none of the Imminst members taking RSV reported lowering of blood glucose. This is the first test for insulin sensitivity.
Before SIRTRIS there was ELIXIR. A company founded by Guarente, the teacher and former mentor of Sinclair. The main purpose of Elixir was to develop drugs to suppress or block Sirt1.
Then there were the experiments with yeast. Calory restriction prolong their happy life. It was speculated that Sir2 should be credited.
When some guys told Sinclair that RSV upregulated Sir2, they fed RSV to yeast and wrote a paper. These yeast lived longer and didn't complain about diabetes.
Metabolic Syndrome and diabetes are in the news like everyday. So they figured there was money to be made in that area.
But what do I know? It's hard for me to keep all that straight.

[zawy]

inawe, on 17-Jan 2008, 04:35 PM, said:

When some guys told Sinclair that RSV upregulated Sir2, they fed RSV to yeast and wrote a paper.

Why is David Sinclair the last name out of 10 or so on the 4 papers to Nature and Science? Is he just doing the directing of post-docs and grad students? I see his lab was acknowledged for providing "discussions and manuscript preparation" for the 2003 article.

[krillin]

zawy, on 17-Jan 2008, 02:15 PM, said:

Why is David Sinclair the last name out of 10 or so on the 4 papers to Nature and Science? Is he just doing the directing of post-docs and grad students? I see his lab was acknowledged for providing "discussions and manuscript preparation" for the 2003 article.

The PI generally puts his name last unless he is an egotist or has terrible students.

[Hedgehog]

zawy, on 14-Jan 2008, 09:43 AM, said:

This is to collect and summarize anecdotal resveratrol reports. I'll try to modify this top post as people post their experience in this thread. Please make posts as brief as possible and follow the format below. Please look for your name in the list below and post to make a change. A change in dosage means a new entry. A relatively close variation in dosing should be averaged to one number. Please delete this list from your message when posting a reply.

People reporting: 29

Benefits:
improved energy/endurance: 13
improved mood: 10
decreased appetite/weight loss: 5
improved hair growth: 5 maybe's
decreased OsteoArthritis (OA): 3
decreased coffee: 2
decreased non-OA pains: 1
require less sleep: 1
increased sex drive: 1

Problems:
increased tendinitis: 6
increased non arthritis, non tendinitis pains: 2
increased obsessive: 2
increased RA arthritis: 1
increased aggression: 1
increased jittery: 2 at beginning (supposedly only on 50%)
laxative: 2 at beginning (supposedly only on 50%)

Please Post in this Format:
name, RESV in g/day, purity, summary of effects

alterego, 0.2,, no RA problems, better mood
alterego, 1.2, 99%, exacerbated rheumatoid arthritis, best mood
anthony_loera,2,99%,improved mood,attitude,well being, recovery, normal (revgenetics supplier)
bixbyte,1,,more hair and nail growth
drmz, 0.6,, knees and ankles
edward, 1,, tennis elbow (increased tennis playing)
edward, 2.3,, no tennis=no tenniselbow
enzyme, 0.6,, hamstring tendinitis
eternalone, 0.3,, improved energy, loss of desire for alcohol, appetite suppressant
fearfrost, 0.5,, quercetin definite energy boost
full_membr, 2,,"crawling out of my skin" with paxil for a day or two when upping the dose from 1 g/d. settled back to 1.5
health_nutty, 0.4,, improved mood and energy, definite appetite suppressant
kenj, 1.1, 99%, achilles tendinitis (run 30-40 mins)
makoss, 0.5,, jolt of energy, appetite suppressant
markymark, 0.225,25%, more energy
matt, ,, ankle tendinitis
maxwatt, 3,, well being and increased energy that returns to baseline after awhile, fewer colds, less arthritis
missminni, 1.75,98%,no more lower back pain from sitting, better knees, cured morton's nueroma, better mood, more agile
missminni_dad,,,improved OA
proteomist, 0.5, 50%, stimulant and laxative effects that subsided
quarter, 0.5, 50%, achilles tendinitis (high impact sprint training)
rhc124, 1.2, 50%, hip pain (worked wonders for my depression and anxiety)
scorpe, 0.8,, fewer colds, less knee pain, increased sex drive
shadowrun, 0.2,, in morning imrpoved energy and alertness, slight headache...will not take at night
stephe_b,2,,back pain, between shoulder blades
tayo,2,,nothing reported, weight lifter experimenting with 5g/d
tintinet, 5, 99%, tennis elbow, hair, "due to playing guitar obsessively" "persistent buoyant mood and general sense of robust physical and mental wellness", decreased appetite, less sleep needed
velopismo, 2.25,98%,increased endurance and power output (road cycling as measured by a powertap), general feeling of well being, aggression, reduced body weight set-point 4%, possible knee pain from applying DMSO/Resv to knee (but could have been by over stressing knee during a sprint).
velopismo_wife,1,98%,very apparent increased energy, weight loss
xanadu, 0.07, 50%, improved energy and mood
zawy, 0.9,, improved energy, hair, loss of desire for coffee, increased obsessive, less arthritis, possible male-pattern baldness improvement after 6 months at 0.2 g/d

Caveats: The laxative effect reported by a few may be due to the emodin in 50% formulations. Tendinitis and arthritis may result from an incresae in activity from an increase in mood/energy/aggression.

Significant increase in energy. I used to cycle about 8-10hrs a week (approx 150-200miles), now in the winter I'm lucky if I get 4hrs. A group of us go out at lunch and do a small climb of about 1000 feet. A person in our group is sponsered and rides at the "elite" level and well this time I was able to lead the way on the flats and pull away on the climb. In effect i think by drafting you save around 15-20% of your energy? This time a didn't draft once on the flats and was to the top of the hill first. The sponserd person cycles a lot so they might be tired but then again they have been riding a lot more and I didnt' draft.

Can't wait to go out and ride again with this person!

[maxwatt]

Cold rain and snow have forced me indoors. I finally set up my Computrainer bicycle ergonometer. I did a virtual 10 mile time trial. My average wattage is almost 20% higher than anything I could do last year at this time, when I first started taking resveratrol. It's on a par with what my power output measured 10 or 12 years ago. I almost suspect something is wrong with the software, or with the load generator.

[health_nutty]

hedgehog_info, on 17-Jan 2008, 03:56 PM, said:

Significant increase in energy. I used to cycle about 8-10hrs a week (approx 150-200miles), now in the winter I'm lucky if I get 4hrs. A group of us go out at lunch and do a small climb of about 1000 feet. A person in our group is sponsered and rides at the "elite" level and well this time I was able to lead the way on the flats and pull away on the climb. In effect i think by drafting you save around 15-20% of your energy? This time a didn't draft once on the flats and was to the top of the hill first. The sponserd person cycles a lot so they might be tired but then again they have been riding a lot more and I didnt' draft.

Can't wait to go out and ride again with this person!

What dosage are you taking and which brand of resveratrol?

[docmaas]

I've been getting soft stools regularly since starting biotivia Transmax 98% 500mg about 1.5 weeks ago. Seems like it is beginning to subside.

I take it dissolved in drinkable yogurt. I successfully dissoved seven caps in 7 oz of yogurt. Will probably try dmso soon. I have a neuroma I'd like to treat with it.

Mike

[niner]

docmaas, on 25-Jan 2008, 01:22 AM, said:

I've been getting soft stools regularly since starting biotivia Transmax 98% 500mg about 1.5 weeks ago. Seems like it is beginning to subside.
I take it dissolved in drinkable yogurt. I successfully dissoved seven caps in 7 oz of yogurt.

Biotivia Transmax is supposed to have some sort of miracle top secret process that improves bioavailability 200%. Does the bottle have a list of ingredients? Pure resveratrol (and 98% is close enough to qualify) has been known to cause GI issues in some people, though not many. The 50% extracts, on the other hand, contain a large amount of Emodin, which is just about guaranteed to give you diarrhea if you take very much of it. I'd be interested to know what the Transmax contains, aside from resveratrol. It's conceivable that the adjuvant compound, if any, is the problem here.

3.5 grams is a pretty hefty dose. Is this your first experience with resveratrol?

[missminni]

niner, on 25-Jan 2008, 01:39 AM, said:

docmaas, on 25-Jan 2008, 01:22 AM, said:

I've been getting soft stools regularly since starting biotivia Transmax 98% 500mg about 1.5 weeks ago. Seems like it is beginning to subside.
I take it dissolved in drinkable yogurt. I successfully dissoved seven caps in 7 oz of yogurt.

Biotivia Transmax is supposed to have some sort of miracle top secret process that improves bioavailability 200%. Does the bottle have a list of ingredients? Pure resveratrol (and 98% is close enough to qualify) has been known to cause GI issues in some people, though not many. The 50% extracts, on the other hand, contain a large amount of Emodin, which is just about guaranteed to give you diarrhea if you take very much of it. I'd be interested to know what the Transmax contains, aside from resveratrol. It's conceivable that the adjuvant compound, if any, is the problem here.

3.5 grams is a pretty hefty dose. Is this your first experience with resveratrol?

I am taking 98% powder. I find that when I take a gram or more at one time, I
get the runs. By taking smaller doses more often, that can be avoided, in my experience. I think taking
it with food might help avoid that problem too. I am going to try that today.
ETA~similar to drinking strong coffee first thing in the morning.

This post has been edited by missminni: 25 January 2008 - 03:22 PM