Antioxidant signalling pathways
From ImmInstWiki
- transcription factor Nrf-2 binds the antioxidant response element (ARE) upstream of genes encoding cytoprotective antioxidant enzymes (Balogun et al., 2003).
- sirtunin-foxo pathway modulating antioxidant enzymes and cell survival (Frescas et al., 2005).
References: - Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R. Biochem J. 2003 May 1;371(Pt 3):887-95. - Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. Frescas D, Valenti L, Accili D. J Biol Chem. 2005 May 27;280(21):20589-95.
